NFIC - nuclear factor I C Gene

Homo sapiens

Also known as CTF; NFI; CTF5; NF-I

Gene ID: 4782 | Gene type: protein coding

About NFIC

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,359,630-3,469,217 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 22.7), ovary (RPKM 18.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NFIC Products(5)

mRNA	Protein	Name
NM_001245002.2	NP_001231931.1	nuclear factor 1 C-type isoform 1
NM_001245004.2	NP_001231933.1	nuclear factor 1 C-type isoform 3
NM_001245005.2	NP_001231934.1	nuclear factor 1 C-type isoform 4
NM_005597.4	NP_005588.2	nuclear factor 1 C-type isoform 5
NM_205843.3	NP_995315.1	nuclear factor 1 C-type isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1524678	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1524678	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1524678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24145797	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	1524678	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1524678	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFIC Protein Structure

NfI_DNAbd_pre-N

MH1

CTF_NFI

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

nuclear factor 1 C-type

CCAAT-box-binding transcription factor

NFIC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	Affinity Chrom	35140242
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	Anti Tag CoIP	25258084
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	BioID	35140242
Intra	NFIC	P08651	PARP1	Homo sapiens	P09874	Anti Bait CoIP	24145797

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mechanical Ectropion

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor

Plexiform Neurofibroma

Neurofibroma Plexiform

Neurofibroma, Plexiform

Optic Nerve Glioma

Glioma Of The Optic Nerve

Blount'S Disease

Blount Disease	Tibia Vara
Osteochondrosis Deformans Tibiae	Osteochondrosis Deformans Tibiae, Familial Infantile Type
Familial Infantile Type Osteochondrosis Deformans Tibiae	Blount-Barber Syndrome
Erlacher-Blount Syndrome	Infantile Tibia Vara
Tibia Vara Blount	Blount Disease, Infantile

Scrotum Neoplasm

Malignant Tumour Of Scrotum	Malignant Scrotal Neoplasm
Malignant Tumor Of Scrotum	Neoplasm Of Scrotum
Scrotal Ca	Scrotal Tumor
Scrotum Cancer	Cancer Of Scrotum
Malignant Neoplasm Of Scrotum	Scrotal Cancer
Malignant Scrotal Tumour	Malignant Neoplasm Of Skin Of Scrotum
Primary Malignant Neoplasm Of Scrotum

Optic Nerve Neoplasm

Optic Nerve Neoplasms	Neoplasm Of Optic Nerve
Tumor Of Second Cranial Nerve	Tumour Of Optic Nerve

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Elephantiasis

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09251	NFIC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NFIC	VGNC	VGNC:75336
Rattus norvegicus	NFIC	RGD	RGD:62016
Felis catus	NFIC	VGNC	VGNC:80638
Canis familiaris	NFIC	VGNC	VGNC:43777
Bos taurus	NFIC	VGNC	VGNC:32040
Mus musculus	NFIC	MGD	MGI:109591

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