NFYB - nuclear transcription factor Y subunit beta Gene

Homo sapiens

Also known as HAP3; CBF-A; CBF-B; NF-YB

Gene ID: 4801 | Gene type: protein coding

About NFYB

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,117,086-104,138,210 (from NCBI)

This gene has 5 transcripts (splice variants), 244 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

NFYB Products(16)

mRNA	Protein	Name
NM_001414518.1	NP_001401447.1	nuclear transcription factor Y subunit beta isoform a
NM_001414519.1	NP_001401448.1	nuclear transcription factor Y subunit beta isoform a
NM_001414520.1	NP_001401449.1	nuclear transcription factor Y subunit beta isoform b
NM_001414521.1	NP_001401450.1	nuclear transcription factor Y subunit beta isoform b
NM_001414522.1	NP_001401451.1	nuclear transcription factor Y subunit beta isoform c
NM_001414523.1	NP_001401452.1	nuclear transcription factor Y subunit beta isoform d
NM_001414524.1	NP_001401453.1	nuclear transcription factor Y subunit beta isoform d
NM_001414525.1	NP_001401454.1	nuclear transcription factor Y subunit beta isoform d
NM_001414526.1	NP_001401455.1	nuclear transcription factor Y subunit beta isoform d
NM_001414527.1	NP_001401456.1	nuclear transcription factor Y subunit beta isoform e
NM_001414528.1	NP_001401457.1	nuclear transcription factor Y subunit beta isoform f
NM_001414529.1	NP_001401458.1	nuclear transcription factor Y subunit beta isoform f
NM_001414530.1	NP_001401459.1	nuclear transcription factor Y subunit beta isoform g
NM_001414531.1	NP_001401460.1	nuclear transcription factor Y subunit beta isoform h
NM_001414532.1	NP_001401461.1	nuclear transcription factor Y subunit beta isoform h
NM_006166.4	NP_006157.1	nuclear transcription factor Y subunit beta isoform b

NFYB Protein Structure

CBFD_NFYB_HMF

0
100
207 a.a.

Protein Preferred Names

Protein Names

nuclear transcription factor Y subunit beta

CAAT box DNA-binding protein subunit B

NFYB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFYB	P25208	NFYA	Homo sapiens	P23511-2	Y2H Array	32296183
Intra	NFYB	P25208	NFYA	Homo sapiens	P23511-2	Anti Tag CoIP	26496610
Intra	NFYB	P25208	NFYA	Homo sapiens	P23511-2	Y2H Prey Pooling	32296183
Intra	NFYB	P25208	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	NFYB	P25208	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	NFYB	P25208	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	NFYB	P25208	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	NFYB	P25208	TP53	Homo sapiens	P04637	Anti Bait CoIP	23734815
Intra	NFYB	P25208	TP53	Homo sapiens	P04637	Anti Bait CoIP	16959611
Intra	NFYB	P25208	NFYA	Homo sapiens	P23511	Y2H Array	25416956
Intra	NFYB	P25208	NFYA	Homo sapiens	P23511	Anti Bait CoIP	16959611
Intra	NFYB	P25208	NFYC	Homo sapiens	Q13952	Anti Tag CoIP	26496610
Intra	NFYB	P25208	NFYC	Homo sapiens	Q13952	X-Ray Diffraction	12401788
Intra	NFYB	P25208	NFYC	Homo sapiens	Q13952	Y2H	21988832
Intra	NFYB	P25208	DRAP1	Homo sapiens	Q14919	Y2H Pooling	16189514
Intra	NFYB	P25208	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	NFYB	P25208	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	NFYB	P25208	POLE4	Homo sapiens	Q9NR33	Validated Y2H	25416956
Intra	NFYB	P25208	POLE4	Homo sapiens	Q9NR33	Validated Y2H	32296183
Intra	NFYB	P25208	POLE4	Homo sapiens	Q9NR33	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cyclosporiasis

Cyclosporosis

Cyclospora Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09272	NFYB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFYB	MGD	MGI:97317
Macaca mulatta	NFYB	VGNC	VGNC:97795
Felis catus	NFYB	VGNC	VGNC:97525
Rattus norvegicus	NFYB	RGD	RGD:3172
Bos taurus	NFYB	VGNC	VGNC:32056
Canis familiaris	NFYB	VGNC	VGNC:43791

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