2. Gene
  3. NFYB - nuclear transcription factor Y subunit beta Gene

NFYB - nuclear transcription factor Y subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HAP3; CBF-A; CBF-B; NF-YB

Gene ID: 4801 | Gene type: protein coding

About NFYB

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,117,086-104,138,210 (from NCBI)

This gene has 5 transcripts (splice variants), 244 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

NFYB Products(16)

mRNA Protein Name
NM_001414518.1 NP_001401447.1 nuclear transcription factor Y subunit beta isoform a
NM_001414519.1 NP_001401448.1 nuclear transcription factor Y subunit beta isoform a
NM_001414520.1 NP_001401449.1 nuclear transcription factor Y subunit beta isoform b
NM_001414521.1 NP_001401450.1 nuclear transcription factor Y subunit beta isoform b
NM_001414522.1 NP_001401451.1 nuclear transcription factor Y subunit beta isoform c
NM_001414523.1 NP_001401452.1 nuclear transcription factor Y subunit beta isoform d
NM_001414524.1 NP_001401453.1 nuclear transcription factor Y subunit beta isoform d
NM_001414525.1 NP_001401454.1 nuclear transcription factor Y subunit beta isoform d
NM_001414526.1 NP_001401455.1 nuclear transcription factor Y subunit beta isoform d
NM_001414527.1 NP_001401456.1 nuclear transcription factor Y subunit beta isoform e
NM_001414528.1 NP_001401457.1 nuclear transcription factor Y subunit beta isoform f
NM_001414529.1 NP_001401458.1 nuclear transcription factor Y subunit beta isoform f
NM_001414530.1 NP_001401459.1 nuclear transcription factor Y subunit beta isoform g
NM_001414531.1 NP_001401460.1 nuclear transcription factor Y subunit beta isoform h
NM_001414532.1 NP_001401461.1 nuclear transcription factor Y subunit beta isoform h
NM_006166.4 NP_006157.1 nuclear transcription factor Y subunit beta isoform b

NFYB Protein Structure

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (58 - 122)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

nuclear transcription factor Y subunit beta

CAAT box DNA-binding protein subunit B

Related Diseases

Diseases Alias
Cyclosporiasis

Cyclosporosis

Cyclospora Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09272 NFYB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NFYB MGD MGI:97317
Macaca mulatta NFYB VGNC VGNC:97795
Felis catus NFYB VGNC VGNC:97525
Rattus norvegicus NFYB RGD RGD:3172
Bos taurus NFYB VGNC VGNC:32056
Canis familiaris NFYB VGNC VGNC:43791