ATP1B1 - ATPase Na+/K+ transporting subunit beta 1 Gene

Homo sapiens

Also known as ATP1B

Gene ID: 481 | Gene type: protein coding

About ATP1B1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,106,690-169,132,719 (from NCBI)

This gene has 19 transcripts (splice variants), 293 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 716.2), brain (RPKM 270.1) and 14 other tissues.

Summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This Enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

ATP1B1 Products(1)

mRNA	Protein	Name
NM_001677.4	NP_001668.1	sodium/potassium-transporting ATPase subunit beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables ATPase activator activity	IGI IGI: Inferred from genetic interaction	16861705	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	10636900	GOA
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	19542013	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17947299	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables protein-macromolecule adaptor activity	IGI IGI: Inferred from genetic interaction	16861705	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23954377	GOA
involved in intracellular potassium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in membrane repolarization	IDA IDA: Inferred from direct assay	19542013	GOA
involved in monoatomic cation transmembrane transport	IGI IGI: Inferred from genetic interaction	20100892	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IGI IGI: Inferred from genetic interaction	18728015	GOA
involved in positive regulation of potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of potassium ion import across plasma membrane	IGI IGI: Inferred from genetic interaction	16861705	GOA
involved in positive regulation of potassium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of sodium ion export across plasma membrane	IGI IGI: Inferred from genetic interaction	18728015	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	16861705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IGI IGI: Inferred from genetic interaction	19751721	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11193188	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	11193188	GOA
located in membrane	IDA IDA: Inferred from direct assay	23954377	GOA
located in organelle membrane	IGI IGI: Inferred from genetic interaction	19751721	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
located in plasma membrane	IGI IGI: Inferred from genetic interaction	19751721	GOA
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	10636900	GOA
part of sodium:potassium-exchanging ATPase complex	IGI IGI: Inferred from genetic interaction	18728015	GOA
part of sodium:potassium-exchanging ATPase complex	IPI IPI: Inferred from physical interaction	16861705	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	16861705	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP1B1 Protein Structure

Na_K-ATPase

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit beta-1

ATPase, Na+/K+ transporting, beta 1 polypeptide

ATP1B1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP1B1	P05026	ATP1A1	Homo sapiens	P05023	Anti Tag CoIP	33961781
Intra	ATP1B1	P05026	ATP1A1	Homo sapiens	P05023	Anti Bait CoIP	25012180
Intra	ATP1B1	P05026	AGTR1	Homo sapiens	P30556	Ub Reconstruction	28298427
Intra	ATP1B1	P05026	WFS1	Homo sapiens	O76024	Anti Bait CoIP	17947299
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Pull Down	25012180
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Anti Bait CoIP	25012180
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Y2H	25012180
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP1B1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75586	ATP1B1 Protein, Human (HEK293, His)	P05026-1 (E63-S303)	≥95%

ATP1B1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82339	ATP1B1 Antibody (YA2084)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Petroclival Meningioma

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1565A	Transdermal Peptide Disulfide TFA	Inhibitor	98.86%	Unkown
HY-P1565	Transdermal Peptide Disulfide	Inhibitor	/	Unkown
HY-RS01186	ATP1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATP1B1	VGNC	VGNC:70176
Rattus norvegicus	ATP1B1	RGD	RGD:2170
Canis familiaris	ATP1B1	VGNC	VGNC:38248
Felis catus	ATP1B1	VGNC	VGNC:68583
Bos taurus	ATP1B1	VGNC	VGNC:26285
Mus musculus	ATP1B1	MGD	MGI:88108
Others	ATP1B1	NCBI

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