NKX3-1 - NK3 homeobox 1 Gene

Homo sapiens

Also known as NKX3; BAPX2; NKX3A; NKX3.1

Gene ID: 4824 | Gene type: protein coding

About NKX3-1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,678,693-23,682,938 (from NCBI)

This gene has 2 transcripts (splice variants), 168 orthologues and 13 paralogues. Biased expression in prostate (RPKM 180.9) and testis (RPKM 17.6).

Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

NKX3-1 Products(2)

mRNA	Protein	Name
NM_001256339.1	NP_001243268.1	homeobox protein Nkx-3.1 isoform 2
NM_006167.4	NP_006158.2	homeobox protein Nkx-3.1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20855495	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18794125	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18296735	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18974119	GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19266349	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18974119	GOA
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	18794125	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	19886863	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17234752	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19780584	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19263243	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	18794125	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20395202	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	17486276	GOA
involved in androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	19886863	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	21056661	GOA
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	18757402	GOA
involved in cellular response to steroid hormone stimulus	IDA IDA: Inferred from direct assay	19886863	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18757402	GOA
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18757402	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18794125	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18360715	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17486276	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	17486276	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19597465	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18360715	GOA
involved in positive regulation of androgen secretion	IDA IDA: Inferred from direct assay	19886863	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	20599703	GOA
involved in positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18360715	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	20599703	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17486276	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20716579	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17486276	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20395202	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20395202	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19797053	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	20395202	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18757402	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	20395202	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX3-1 Protein Structure

Homeobox

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

homeobox protein Nkx-3.1

NK homeobox, family 3, A

NKX3-1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NKX3-1	Q99801	CD200R1L	Homo sapiens	Q6Q8B3	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	CD200R1L	Homo sapiens	Q6Q8B3	Y2H Array	32296183
Intra	NKX3-1	Q99801	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	NKX3-1	Q99801	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	NKX3-1	Q99801	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	32296183
Intra	NKX3-1	Q99801	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	TOP1	Homo sapiens	P11387	Pull Down	17234752
Intra	NKX3-1	Q99801	TOP1	Homo sapiens	P11387	Confocal	17234752

Cross: Cross-species interaction Intra: Intraspecies interaction

NKX3-1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82572	NKX3.1 Antibody (YA2317)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Rete Testis Neoplasm

Rete Testis Adenocarcinoma

Adenocarcinoma Of Rete Testis

Adenocarcinoma Of The Rete Testis

Salivary Gland Mucinous Adenocarcinoma

Anal Spasm

Proctospasm	Anorectal Spasm
Rectal Spasm

Cervical Adenoid Basal Carcinoma

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Prostatitis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Atrophy Of Prostate

Adenoid Basal Cell Carcinoma

Skin Adenoid Basal Cell Carcinoma

Basal Cell Carcinoma - Adenoid

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Bladder Small Cell Carcinoma

Small Cell Bladder Cancer	Small Cell Carcinoma Of The Bladder
Poorly Differentiated Neuroendocrine Carcinoma Of The Bladder	Sccb
Small Cell Bladder Carcinoma	Small Cell Carcinoma Of The Urinary Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09333	NKX3-1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NKX3-1	VGNC	VGNC:32105
Felis catus	NKX3-1	VGNC	VGNC:78533
Mus musculus	NKX3-1	MGD	MGI:97352
Rattus norvegicus	NKX3-1	RGD	RGD:1305369
Macaca mulatta	NKX3-1	VGNC	VGNC:75355

Name
Email *

	Sorry, but the email address you supplied was invalid.