NME2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

Homo sapiens

Also known as PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2

Gene ID: 4831 | Gene type: protein coding

About NME2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:51,165,536-51,171,744 (from NCBI)

This gene has 9 transcripts (splice variants), 118 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues.

Summary

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

NME2 Products(5)

mRNA	Protein	Name
NM_001018137.3	NP_001018147.1	nucleoside diphosphate kinase B isoform a
NM_001018138.1	NP_001018148.1	nucleoside diphosphate kinase B isoform a
NM_001018139.2	NP_001018149.1	nucleoside diphosphate kinase B isoform a
NM_001198682.2	NP_001185611.1	nucleoside diphosphate kinase B isoform b
NM_002512.4	NP_002503.1	nucleoside diphosphate kinase B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19435876	GOA
enables G-quadruplex DNA binding	IDA IDA: Inferred from direct assay	25679041	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	19435876	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	1851158	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11919189	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	8392752	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11919189	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in nucleoside triphosphate biosynthetic process	IDA IDA: Inferred from direct assay	1851158	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8392752	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19435876	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15703214	GOA
involved in regulation of epidermis development	IMP IMP: Inferred from mutant phenotype	16862176	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	11919189	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15703214	GOA
NOT located in focal adhesion	IDA IDA: Inferred from direct assay	11919189	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11919189	GOA
located in ruffle	IDA IDA: Inferred from direct assay	11919189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleoside diphosphate kinase B

HEL-S-155an

Related Diseases

Diseases

Alias

Endometrium Carcinoma In Situ

Carcinoma In Situ Of Endometrium

Endometrial Carcinoma In Situ

Nemaline Myopathy 2

NEM2	Nemaline Myopathy 2, Autosomal Recessive
Nemaline Myopathy, Type 2	Neb-Related Nemaline Myopathy
Myopathy, Nemaline, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6747	Stauprimide	Inhibitor	99.45%	Unkown
HY-RS09372	NME1-NME2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09373	NME2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NME2	VGNC	VGNC:108102
Rattus norvegicus	NME2	RGD	RGD:619877
Mus musculus	NME2	MGD	MGI:97356

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