MED21 - mediator complex subunit 21 Gene

Homo sapiens

Also known as SRB7; SURB7; hSrb7

Gene ID: 9412 | Gene type: protein coding

About MED21

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,022,558-27,038,951 (from NCBI)

This gene has 7 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in adrenal (RPKM 13.1), testis (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

MED21 Products(2)

mRNA	Protein	Name
NM_001271811.2	NP_001258740.1	mediator of RNA polymerase II transcription subunit 21 isoform 2
NM_004264.5	NP_004255.2	mediator of RNA polymerase II transcription subunit 21 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14638676	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12037571	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12037571	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	12037571	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED21 Protein Structure

Med21

0
100
144 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 21

RNA polymerase II holoenzyme component SRB7

MED21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED21	Q13503	SSC5D	Homo sapiens	A1L4H1	Validated Y2H	25416956
Intra	MED21	Q13503	SSC5D	Homo sapiens	A1L4H1	Y2H Array	25416956
Intra	MED21	Q13503	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	32296183
Intra	MED21	Q13503	TRIM72	Homo sapiens	Q6ZMU5	Validated Y2H	32296183
Intra	MED21	Q13503	TRIM72	Homo sapiens	Q6ZMU5	Y2H Array	32296183
Intra	MED21	Q13503	MED1	Homo sapiens	Q15648	TAP	24981860
Intra	MED21	Q13503	MED1	Homo sapiens	Q15648	Anti Tag CoIP	33961781
Intra	MED21	Q13503	MED1	Homo sapiens	Q15648	Anti Tag CoIP	28514442
Intra	MED21	Q13503	MED1	Homo sapiens	Q15648	Anti Tag CoIP	35271311
Intra	MED21	Q13503	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	35271311
Intra	MED21	Q13503	MED4	Homo sapiens	Q9NPJ6	TAP	24981860
Intra	MED21	Q13503	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	33961781
Intra	MED21	Q13503	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	28514442
Intra	MED21	Q13503	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	24882805
Intra	MED21	Q13503	MED7	Homo sapiens	O43513	Anti Tag CoIP	33961781
Intra	MED21	Q13503	MED7	Homo sapiens	O43513	Anti Tag CoIP	28514442
Intra	MED21	Q13503	MED7	Homo sapiens	O43513	Anti Tag CoIP	24882805
Intra	MED21	Q13503	MED7	Homo sapiens	O43513	Anti Tag CoIP	35271311
Intra	MED21	Q13503	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	24882805
Intra	MED21	Q13503	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	33961781
Intra	MED21	Q13503	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	35271311
Intra	MED21	Q13503	MED9	Homo sapiens	Q9NWA0	TAP	24981860
Intra	MED21	Q13503	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	28514442
Intra	MED21	Q13503	LSAMP	Homo sapiens	Q13449	Y2H Array	32814053
Intra	MED21	Q13503	LSAMP	Homo sapiens	Q13449	Validated Y2H	32814053
Intra	MED21	Q13503	LSAMP	Homo sapiens	Q13449	Y2H Pooling	32814053
Intra	MED21	Q13503	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	25416956
Intra	MED21	Q13503	BLOC1S6	Homo sapiens	Q9UL45	Y2H Array	25416956
Intra	MED21	Q13503	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	25416956
Intra	MED21	Q13503	ZNF655	Homo sapiens	Q8N720	Validated Y2H	25416956
Intra	MED21	Q13503	ZNF655	Homo sapiens	Q8N720	Y2H Array	25416956
Intra	MED21	Q13503	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hemopericardium

Haemopericardium	Pericardial Effusion
Haematopericardium	Pneumohemopericardium
Pericardium Haemorrhage	Haemorrhagic Pericarditis

Hemopneumothorax

Haemopneumothorax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08292	MED21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED21	MGD	MGI:1347064
Canis familiaris	MED21	VGNC	VGNC:57444
Rattus norvegicus	MED21	RGD	RGD:1309836
Macaca mulatta	MED21	VGNC	VGNC:74501
Bos taurus	MED21	VGNC	VGNC:31358

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