1. Gene
  2. NMI - N-myc and STAT interactor Gene

NMI - N-myc and STAT interactor Gene

Homo sapiens
Gene ID: 9111 | Gene type: protein coding

About NMI

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,270,470-151,289,668 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues.

Summary

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in Cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

NMI Products(1)

mRNA Protein Name
NM_004688.3 NP_004679.2 N-myc-interactor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9989503 GOA
Biological Process GO Annotation Evidence Reference Source
involved in macrophage activation involved in immune response IDA
IDA: Inferred from direct assay
29038465 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
29350881 GOA
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
26342464 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
29350881 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
29038465 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9781816 GOA
located in cytosol IDA
IDA: Inferred from direct assay
10779520 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
29038465 GOA
located in membrane IDA
IDA: Inferred from direct assay
10950963 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9781816 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMI Protein Structure

IFP_35_N

IFP_35_N: Interferon-induced 35 kDa protein (IFP 35) N-terminus (29 - 104)

NID

NID: Nmi/IFP 35 domain (NID) (105 - 192)

NID

NID: Nmi/IFP 35 domain (NID) (203 - 291)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

N-myc-interactor

NMI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NMI Q13287 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra NMI Q13287 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra NMI Q13287 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra NMI Q13287 GOLGA8DP Homo sapiens Q0D2H9
Validated Y2H
25416956
Intra NMI Q13287 GOLGA8DP Homo sapiens Q0D2H9
Y2H Array
25416956
Intra NMI Q13287 GOLGA8DP Homo sapiens Q0D2H9
Y2H Prey Pooling
25416956
Intra NMI Q13287 GCSH Homo sapiens Q53XL7
Y2H Array
25416956
Intra NMI Q13287 GCSH Homo sapiens Q53XL7
Y2H Prey Pooling
25416956
Intra NMI Q13287 CNKSR3 Homo sapiens Q6P9H4
Validated Y2H
25416956
Intra NMI Q13287 CNKSR3 Homo sapiens Q6P9H4
Y2H Array
25416956
Intra NMI Q13287 CNKSR3 Homo sapiens Q6P9H4
Y2H Prey Pooling
25416956
Intra NMI Q13287 HSPA8 Homo sapiens Q96IS6
Validated Y2H
25416956
Intra NMI Q13287 HSPA8 Homo sapiens Q96IS6
Y2H Prey Pooling
25416956
Intra NMI Q13287 HSPA8 Homo sapiens Q96IS6
Y2H Array
25416956
Intra NMI Q13287 BRAT1 Homo sapiens Q6PJG6
Validated Y2H
32296183
Intra NMI Q13287 BRAT1 Homo sapiens Q6PJG6
Y2H Array
32296183
Intra NMI Q13287 BRAT1 Homo sapiens Q6PJG6
Y2H Prey Pooling
32296183
Intra NMI Q13287 SFR1 Homo sapiens Q86XK3
Validated Y2H
25416956
Intra NMI Q13287 SFR1 Homo sapiens Q86XK3
Y2H Array
25416956
Intra NMI Q13287 SFR1 Homo sapiens Q86XK3
Y2H Prey Pooling
25416956
Intra NMI Q13287 SOX10 Homo sapiens P56693
Anti Tag CoIP
16214168
Intra NMI Q13287 STAT5B Homo sapiens P51692
Anti Tag CoIP
9989503
Intra NMI Q13287 STAT5B Homo sapiens P51692
Pull Down
9989503
Intra NMI Q13287 STAT6 Homo sapiens P42226
Pull Down
9989503
Intra NMI Q13287 SNAPC5 Homo sapiens O75971-2
Y2H Prey Pooling
32296183
Intra NMI Q13287 SNAPC5 Homo sapiens O75971-2
Y2H Array
32296183
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3-2
Y2H Prey Pooling
32296183
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3-2
Y2H Array
32296183
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3-2
Validated Y2H
32296183
Intra NMI Q13287 ANKRD13C-DT Homo sapiens Q9XRX5-2
Validated Y2H
32296183
Intra NMI Q13287 MYOM3 Homo sapiens Q5VTT5-2
Validated Y2H
32296183
Intra NMI Q13287 MYOM3 Homo sapiens Q5VTT5-2
Y2H Array
32296183
Intra NMI Q13287 MYOM3 Homo sapiens Q5VTT5-2
Y2H Prey Pooling
32296183
Intra NMI Q13287 IFI35 Homo sapiens P80217-2
Y2H Prey Pooling
32296183
Intra NMI Q13287 IFI35 Homo sapiens P80217-2
Anti Tag CoIP
28514442
Intra NMI Q13287 IFI35 Homo sapiens P80217-2
Y2H Array
32296183
Intra NMI Q13287 TRIM72 Homo sapiens Q6ZMU5
Validated Y2H
32296183
Intra NMI Q13287 COPS7B Homo sapiens Q9H9Q2
Validated Y2H
25416956
Intra NMI Q13287 COPS7B Homo sapiens Q9H9Q2
Validated Y2H
32296183
Intra NMI Q13287 COPS7B Homo sapiens Q9H9Q2
Y2H Array
25416956
Intra NMI Q13287 TUBA3E Homo sapiens Q6PEY2
Validated Y2H
32296183
Intra NMI Q13287 TUBA3E Homo sapiens Q6PEY2
Validated Y2H
25416956
Intra NMI Q13287 TUBA3E Homo sapiens Q6PEY2
Y2H Prey Pooling
25416956
Intra NMI Q13287 C9orf72 Homo sapiens Q96LT7
Validated Y2H
25416956
Intra NMI Q13287 C9orf72 Homo sapiens Q96LT7
Y2H Array
25416956
Intra NMI Q13287 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra NMI Q13287 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra NMI Q13287 TRAF5 Homo sapiens O00463
Y2H Array
25416956
Intra NMI Q13287 BRMS1 Homo sapiens Q9HCU9
Y2H Array
25416956
Intra NMI Q13287 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
25416956
Intra NMI Q13287 BRMS1 Homo sapiens Q9HCU9
Y2H Array
31515488
Intra NMI Q13287 TRAF5 Homo sapiens O00463
BFG-2H
27107012
Intra NMI Q13287 TXLNB Homo sapiens Q8N3L3
Validated Y2H
32296183
Intra NMI Q13287 TXLNB Homo sapiens Q8N3L3
Y2H Prey Pooling
25416956
Intra NMI Q13287 TXLNB Homo sapiens Q8N3L3
Validated Y2H
25416956
Intra NMI Q13287 MAD2L1BP Homo sapiens Q15013
Y2H Prey Pooling
25416956
Intra NMI Q13287 GCSH Homo sapiens P23434
Y2H Pooling
16189514
Intra NMI Q13287 THAP8 Homo sapiens Q8NA92
Validated Y2H
32296183
Intra NMI Q13287 HGS Homo sapiens O14964
Y2H Pooling
16189514
Intra NMI Q13287 EMILIN1 Homo sapiens Q9Y6C2
Validated Y2H
25416956
Intra NMI Q13287 EMILIN1 Homo sapiens Q9Y6C2
Y2H Array
25416956
Intra NMI Q13287 EMILIN1 Homo sapiens Q9Y6C2
Y2H Pooling
16189514
Intra NMI Q13287 MTMR9 Homo sapiens Q96QG7
Validated Y2H
25416956
Intra NMI Q13287 MTMR9 Homo sapiens Q96QG7
Y2H Prey Pooling
32296183
Intra NMI Q13287 MTMR9 Homo sapiens Q96QG7
Validated Y2H
32296183
Intra NMI Q13287 MTMR9 Homo sapiens Q96QG7
Y2H Prey Pooling
25416956
Intra NMI Q13287 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
25416956
Intra NMI Q13287 C1orf216 Homo sapiens Q8TAB5
Y2H Array
25416956
Intra NMI Q13287 SNAPC5 Homo sapiens O75971
Validated Y2H
25416956
Intra NMI Q13287 SNAPC5 Homo sapiens O75971
Y2H Array
25416956
Intra NMI Q13287 SNAPC5 Homo sapiens O75971
Y2H Prey Pooling
25416956
Intra NMI Q13287 SNAPC5 Homo sapiens O75971
Y2H Pooling
16189514
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3
Y2H Array
25416956
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3
Y2H Pooling
16189514
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3
Y2H Prey Pooling
25416956
Intra NMI Q13287 HDDC3 Homo sapiens Q8N4P3
Validated Y2H
25416956
Intra NMI Q13287 ANKRD13C-DT Homo sapiens Q9XRX5
Y2H Pooling
16189514
Intra NMI Q13287 ANKRD13C-DT Homo sapiens Q9XRX5
Y2H Prey Pooling
25416956
Intra NMI Q13287 ANKRD13C-DT Homo sapiens Q9XRX5
Validated Y2H
25416956
Intra NMI Q13287 ANKRD13C-DT Homo sapiens Q9XRX5
Y2H Array
25416956
Intra NMI Q13287 SCEL Homo sapiens O95171
Y2H Array
25416956
Intra NMI Q13287 SCEL Homo sapiens O95171
Y2H
21516116
Intra NMI Q13287 MTMR6 Homo sapiens Q9Y217
Validated Y2H
25416956
Intra NMI Q13287 MTMR6 Homo sapiens Q9Y217
Y2H Array
25416956
Intra NMI Q13287 LCA5L Homo sapiens O95447
Y2H Array
25416956
Intra NMI Q13287 LCA5L Homo sapiens O95447
Validated Y2H
25416956
Intra NMI Q13287 LCA5L Homo sapiens O95447
Y2H Prey Pooling
25416956
Intra NMI Q13287 a8k2r3_human Homo sapiens A8K2R3
Validated Y2H
25416956
Intra NMI Q13287 a8k2r3_human Homo sapiens A8K2R3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mouth Disease

Mouth Diseases

Mouth Disorders

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta NMI VGNC VGNC:75359
Mus musculus NMI MGD MGI:1928368
Felis catus NMI VGNC VGNC:68505
Canis familiaris NMI VGNC VGNC:43861
Rattus norvegicus NMI RGD RGD:1311721
Bos taurus NMI VGNC VGNC:56132