NMI - N-myc and STAT interactor Gene

Homo sapiens

Gene ID: 9111 | Gene type: protein coding

About NMI

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,270,470-151,289,668 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues.

Summary

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and Other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in Cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

NMI Products(1)

mRNA	Protein	Name
NM_004688.3	NP_004679.2	N-myc-interactor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9989503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in macrophage activation involved in immune response	IDA IDA: Inferred from direct assay	29038465	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	29350881	GOA
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	26342464	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	29350881	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	29038465	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9781816	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10779520	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	29038465	GOA
located in membrane	IDA IDA: Inferred from direct assay	10950963	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9781816	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMI Protein Structure

IFP_35_N

NID

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

N-myc-interactor

NMI Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NMI	Q13287	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	NMI	Q13287	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	NMI	Q13287	GOLGA8DP	Homo sapiens	Q0D2H9	Validated Y2H	25416956
Intra	NMI	Q13287	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	NMI	Q13287	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	GCSH	Homo sapiens	Q53XL7	Y2H Array	25416956
Intra	NMI	Q13287	GCSH	Homo sapiens	Q53XL7	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	CNKSR3	Homo sapiens	Q6P9H4	Validated Y2H	25416956
Intra	NMI	Q13287	CNKSR3	Homo sapiens	Q6P9H4	Y2H Array	25416956
Intra	NMI	Q13287	CNKSR3	Homo sapiens	Q6P9H4	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	HSPA8	Homo sapiens	Q96IS6	Validated Y2H	25416956
Intra	NMI	Q13287	HSPA8	Homo sapiens	Q96IS6	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	HSPA8	Homo sapiens	Q96IS6	Y2H Array	25416956
Intra	NMI	Q13287	BRAT1	Homo sapiens	Q6PJG6	Validated Y2H	32296183
Intra	NMI	Q13287	BRAT1	Homo sapiens	Q6PJG6	Y2H Array	32296183
Intra	NMI	Q13287	BRAT1	Homo sapiens	Q6PJG6	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	SFR1	Homo sapiens	Q86XK3	Validated Y2H	25416956
Intra	NMI	Q13287	SFR1	Homo sapiens	Q86XK3	Y2H Array	25416956
Intra	NMI	Q13287	SFR1	Homo sapiens	Q86XK3	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	SOX10	Homo sapiens	P56693	Anti Tag CoIP	16214168
Intra	NMI	Q13287	STAT5B	Homo sapiens	P51692	Anti Tag CoIP	9989503
Intra	NMI	Q13287	STAT5B	Homo sapiens	P51692	Pull Down	9989503
Intra	NMI	Q13287	STAT6	Homo sapiens	P42226	Pull Down	9989503
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971-2	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971-2	Y2H Array	32296183
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3-2	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3-2	Y2H Array	32296183
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3-2	Validated Y2H	32296183
Intra	NMI	Q13287	ANKRD13C-DT	Homo sapiens	Q9XRX5-2	Validated Y2H	32296183
Intra	NMI	Q13287	MYOM3	Homo sapiens	Q5VTT5-2	Validated Y2H	32296183
Intra	NMI	Q13287	MYOM3	Homo sapiens	Q5VTT5-2	Y2H Array	32296183
Intra	NMI	Q13287	MYOM3	Homo sapiens	Q5VTT5-2	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	IFI35	Homo sapiens	P80217-2	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	IFI35	Homo sapiens	P80217-2	Anti Tag CoIP	28514442
Intra	NMI	Q13287	IFI35	Homo sapiens	P80217-2	Y2H Array	32296183
Intra	NMI	Q13287	TRIM72	Homo sapiens	Q6ZMU5	Validated Y2H	32296183
Intra	NMI	Q13287	COPS7B	Homo sapiens	Q9H9Q2	Validated Y2H	25416956
Intra	NMI	Q13287	COPS7B	Homo sapiens	Q9H9Q2	Validated Y2H	32296183
Intra	NMI	Q13287	COPS7B	Homo sapiens	Q9H9Q2	Y2H Array	25416956
Intra	NMI	Q13287	TUBA3E	Homo sapiens	Q6PEY2	Validated Y2H	32296183
Intra	NMI	Q13287	TUBA3E	Homo sapiens	Q6PEY2	Validated Y2H	25416956
Intra	NMI	Q13287	TUBA3E	Homo sapiens	Q6PEY2	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	C9orf72	Homo sapiens	Q96LT7	Validated Y2H	25416956
Intra	NMI	Q13287	C9orf72	Homo sapiens	Q96LT7	Y2H Array	25416956
Intra	NMI	Q13287	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	NMI	Q13287	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	NMI	Q13287	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	NMI	Q13287	BRMS1	Homo sapiens	Q9HCU9	Y2H Array	25416956
Intra	NMI	Q13287	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	BRMS1	Homo sapiens	Q9HCU9	Y2H Array	31515488
Intra	NMI	Q13287	TRAF5	Homo sapiens	O00463	BFG-2H	27107012
Intra	NMI	Q13287	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	NMI	Q13287	TXLNB	Homo sapiens	Q8N3L3	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	25416956
Intra	NMI	Q13287	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	GCSH	Homo sapiens	P23434	Y2H Pooling	16189514
Intra	NMI	Q13287	THAP8	Homo sapiens	Q8NA92	Validated Y2H	32296183
Intra	NMI	Q13287	HGS	Homo sapiens	O14964	Y2H Pooling	16189514
Intra	NMI	Q13287	EMILIN1	Homo sapiens	Q9Y6C2	Validated Y2H	25416956
Intra	NMI	Q13287	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Array	25416956
Intra	NMI	Q13287	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Pooling	16189514
Intra	NMI	Q13287	MTMR9	Homo sapiens	Q96QG7	Validated Y2H	25416956
Intra	NMI	Q13287	MTMR9	Homo sapiens	Q96QG7	Y2H Prey Pooling	32296183
Intra	NMI	Q13287	MTMR9	Homo sapiens	Q96QG7	Validated Y2H	32296183
Intra	NMI	Q13287	MTMR9	Homo sapiens	Q96QG7	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	25416956
Intra	NMI	Q13287	C1orf216	Homo sapiens	Q8TAB5	Y2H Array	25416956
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971	Validated Y2H	25416956
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971	Y2H Array	25416956
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	SNAPC5	Homo sapiens	O75971	Y2H Pooling	16189514
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3	Y2H Array	25416956
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3	Y2H Pooling	16189514
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	HDDC3	Homo sapiens	Q8N4P3	Validated Y2H	25416956
Intra	NMI	Q13287	ANKRD13C-DT	Homo sapiens	Q9XRX5	Y2H Pooling	16189514
Intra	NMI	Q13287	ANKRD13C-DT	Homo sapiens	Q9XRX5	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	ANKRD13C-DT	Homo sapiens	Q9XRX5	Validated Y2H	25416956
Intra	NMI	Q13287	ANKRD13C-DT	Homo sapiens	Q9XRX5	Y2H Array	25416956
Intra	NMI	Q13287	SCEL	Homo sapiens	O95171	Y2H Array	25416956
Intra	NMI	Q13287	SCEL	Homo sapiens	O95171	Y2H	21516116
Intra	NMI	Q13287	MTMR6	Homo sapiens	Q9Y217	Validated Y2H	25416956
Intra	NMI	Q13287	MTMR6	Homo sapiens	Q9Y217	Y2H Array	25416956
Intra	NMI	Q13287	LCA5L	Homo sapiens	O95447	Y2H Array	25416956
Intra	NMI	Q13287	LCA5L	Homo sapiens	O95447	Validated Y2H	25416956
Intra	NMI	Q13287	LCA5L	Homo sapiens	O95447	Y2H Prey Pooling	25416956
Intra	NMI	Q13287	a8k2r3_human	Homo sapiens	A8K2R3	Validated Y2H	25416956
Intra	NMI	Q13287	a8k2r3_human	Homo sapiens	A8K2R3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mouth Disease

Mouth Diseases

Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101540	NMI 8739	Agonist	99.02%	Unkown
HY-RS09381	NMI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NMI	VGNC	VGNC:75359
Mus musculus	NMI	MGD	MGI:1928368
Felis catus	NMI	VGNC	VGNC:68505
Canis familiaris	NMI	VGNC	VGNC:43861
Rattus norvegicus	NMI	RGD	RGD:1311721
Bos taurus	NMI	VGNC	VGNC:56132

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