2. Gene
  3. ODF1 - outer dense fiber of sperm tails 1 Gene

ODF1 - outer dense fiber of sperm tails 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB

Gene ID: 4956 | Gene type: protein coding

About ODF1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,551,589-102,561,018 (from NCBI)

This gene has 2 transcripts (splice variants) and 107 orthologues. Restricted expression toward testis (RPKM 125.7).

Summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

ODF1 Products(1)

mRNA Protein Name
NM_024410.4 NP_077721.2 outer dense fiber protein 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21597245 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ODF1 Protein Structure

HSP20

HSP20: Hsp20/alpha crystallin family (129 - 190)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

outer dense fiber protein 1

cancer/testis antigen 133

ODF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ODF1 Q14990 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
25416956
Intra
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
ODF1 Q14990 LCE1C Homo sapiens Q5T751
Validated Y2H
32296183
Intra
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
ODF1 Q14990 P4HB Homo sapiens P07237
Y2H Array
32296183
Intra
ODF1 Q14990 P4HB Homo sapiens P07237
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ODF1 Q14990 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ODF1 Q14990 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
ODF1 Q14990 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
ODF1 Q14990 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
Intra
ODF1 Q14990 KRT86 Homo sapiens O43790
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuronopathy, Distal Hereditary Motor, Type Iic

HMN2C

Hmn Iic

Dhmn2c

Distal Hereditary Motor Neuronopathy Type 2c

Distal Hereditary Motor Neuropathy Type Iic

Neuronopathy, Distal Hereditary Motor, Type 2c

Neuropathy, Distal Hereditary Motor, Type Iic

Neuronopathy, Distal Hereditary Motor, 2c

Dhmn Iic

Neuropathy, Motor, Distal, Hereditary, Type 2c
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Infertility
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09751 ODF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ODF1 RGD RGD:3228
Bos taurus ODF1 VGNC VGNC:32400
Mus musculus ODF1 MGD MGI:97424
Macaca mulatta ODF1 VGNC VGNC:75579
Canis familiaris ODF1 VGNC VGNC:44098