2. Gene
  3. KRT86 - keratin 86 Gene

KRT86 - keratin 86 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HB6; Hb1; K86; MNX; KRTHB1; KRTHB6

Gene ID: 3892 | Gene type: protein coding

About KRT86

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,274,645-52,309,163 (from NCBI)

This gene has 3 transcripts (splice variants), 44 orthologues, 68 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016]

KRT86 Products(1)

mRNA Protein Name
NM_001320198.2 NP_001307127.1 keratin, type II cuticular Hb6
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in keratin filament IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT86 Protein Structure

Filament

Filament: Intermediate filament protein (105 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
Protein Preferred Names Protein Names

keratin, type II cuticular Hb6

hair keratin K2.11

KRT86 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT86 O43790 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
KRT86 O43790 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
KRT86 O43790 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
KRT86 O43790 RTP5 Homo sapiens Q14D33
Validated Y2H
32296183
Intra
KRT86 O43790 OLIG3 Homo sapiens Q7RTU3
Validated Y2H
32296183
Intra
KRT86 O43790 ODF1 Homo sapiens Q14990
Validated Y2H
32296183
Intra
KRT86 O43790 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
KRT86 O43790 KRT32 Homo sapiens Q14532
Y2H Array
32296183
Intra
KRT86 O43790 KRT32 Homo sapiens Q14532
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT32 Homo sapiens Q14532
Validated Y2H
32296183
Intra
KRT86 O43790 KRT37 Homo sapiens O76014
Validated Y2H
32296183
Intra
KRT86 O43790 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra
KRT86 O43790 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
KRT86 O43790 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra
KRT86 O43790 KRT38 Homo sapiens O76015
Validated Y2H
32296183
Intra
KRT86 O43790 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra
KRT86 O43790 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
KRT86 O43790 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
KRT86 O43790 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KRT86 O43790 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KRT86 O43790 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
KRT86 O43790 CAMK2B Homo sapiens Q13554-3
Validated Y2H
32296183
Intra
KRT86 O43790 CEP57 Homo sapiens Q86XR8-3
Y2H Array
32296183
Intra
KRT86 O43790 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra
KRT86 O43790 CEP57 Homo sapiens Q86XR8-3
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT39 Homo sapiens Q6A163
Complementation
32296183
Intra
KRT86 O43790 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
KRT86 O43790 KRT39 Homo sapiens Q6A163
MAPPIT
32296183
Intra
KRT86 O43790 KRT39 Homo sapiens Q6A163
Validated Y2H
32296183
Intra
KRT86 O43790 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
KRT86 O43790 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT36 Homo sapiens O76013-2
Validated Y2H
32296183
Intra
KRT86 O43790 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
KRT86 O43790 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra
KRT86 O43790 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra
KRT86 O43790 KRT28 Homo sapiens Q7Z3Y7
Validated Y2H
32296183
Intra
KRT86 O43790 IL16 Homo sapiens Q14005-2
Validated Y2H
32296183
Intra
KRT86 O43790 IL16 Homo sapiens Q14005-2
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
KRT86 O43790 JOSD1 Homo sapiens Q15040
Validated Y2H
32296183
Intra
KRT86 O43790 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
KRT86 O43790 KRT76 Homo sapiens Q01546
Validated Y2H
32296183
Intra
KRT86 O43790 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
KRT86 O43790 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
KRT86 O43790 RESF1 Homo sapiens Q9HCM1
Validated Y2H
32296183
Intra
KRT86 O43790 KRT16 Homo sapiens P08779
Validated Y2H
32296183
Intra
KRT86 O43790 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
KRT86 O43790 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
KRT86 O43790 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra
KRT86 O43790 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
KRT86 O43790 NUTF2 Homo sapiens P61970
Validated Y2H
32296183
Intra
KRT86 O43790 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
KRT86 O43790 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
KRT86 O43790 KRT14 Homo sapiens P02533
Validated Y2H
32296183
Intra
KRT86 O43790 KRT14 Homo sapiens P02533
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra
KRT86 O43790 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
KRT86 O43790 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra
KRT86 O43790 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT15 Homo sapiens P19012
Validated Y2H
32296183
Intra
KRT86 O43790 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra
KRT86 O43790 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT19 Homo sapiens P08727
Validated Y2H
32296183
Intra
KRT86 O43790 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
KRT86 O43790 ZNF414 Homo sapiens Q96IQ9
Validated Y2H
32296183
Intra
KRT86 O43790 CDK18 Homo sapiens Q07002
Validated Y2H
32296183
Intra
KRT86 O43790 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
KRT86 O43790 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
KRT86 O43790 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
Intra
KRT86 O43790 SHC3 Homo sapiens Q92529
Validated Y2H
32296183
Intra
KRT86 O43790 MAPKBP1 Homo sapiens O60336
Validated Y2H
32296183
Intra
KRT86 O43790 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
KRT86 O43790 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KRT86 O43790 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome
Hair Disease

Hair Diseases

Hair Anomaly

Hair Disorder

Hair Problems
Black Piedra

Tinea Nodosa

Trichomycosis Nodularis

Chignon Disease
Keratosis

Actinic Keratosis

Hyperkeratosis
Hypotrichosis 6

HYPT6

Lah1

Hypotrichosis, Localized, Autosomal Recessive

Monilethrix-Like Hypotrichosis

Hypotrichosis, Localized, Autosomal Recessive 1

Lah

Htl

Autosomal Recessive Localized Hypotrichosis

Hypotrichosis Localized Autosomal Recessive

Hypotrichosis Localized Autosomal Recessive 1

Hypotrichosis, Type 6
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Naegeli-Franceschetti-Jadassohn Syndrome

Naegeli Syndrome

Nfj Syndrome

NFJS

Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy

Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis

Dpr

Franceschetti-Jadassohn Syndrome

Nfjs/Dpr
Hypotrichosis
Alopecia
Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset
Loose Anagen Hair Syndrome

Loose Anagen Syndrome

LAHS
Diffuse Alopecia Areata

Diffuse Alopecia
Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia

ECTD4

Ectodermal Dysplasia, Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair/Nail Type

Hned

Hair-Nail Ectodermal Dysplasia

Phned

Ectodermal Dysplasia Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair-Nail Type

Dysplasia, Ectodermal, Type 4, Hair/Nail
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy

Winged Helix Deficiency

Alymphoid Cystic Thymic Dysgenesis

Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome

Pignata Guarino Syndrome

TIDAND

T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy

Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency

Severe Combined Immunodeficiency Due To Foxn1 Deficiency

Foxn1 Deficiency

Nude/Scid

Nude/Severe Combined Immunodeficiency

Scid Due To Foxn1 Deficiency

Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Loeys-Dietz Syndrome 3

LDS3

Aneurysms-Osteoarthritis Syndrome

Loeys-Dietz Syndrome With Osteoarthritis

Aneurysm-Osteoarthritis Syndrome

Lds1c

Loeys-Dietz Syndrome, Type 3

Loeys-Dietz Syndrome, Type 1c, Formerly

Lds1c, Formerly

Loeys-Dietz Syndrome Type 1c

Loeys-Dietz Syndrome Type 3

Aneurysm - Osteoarthritis Syndrome

Loeys-Dietz Syndrome, Type 1c

Aos

Loeys-Dietz Syndrome 1c
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM
Atrichia With Papular Lesions

Papular Atrichia

APL

Congenital Atrichia
Agnathia-Otocephaly Complex

Otocephaly

Holoprosencephaly-Agnathia

Dysgnathia Complex Agnathia-Holoprosencephaly

AGOTC

Agnathia-Holoprosencephaly-Situs Inversus Syndrome

Dysgnathia Complex

Agnathia-Holoprosencephaly

Cervical Auricle
White Piedra

Tinea Blanca

Trichosporosis Nodosa
Microphthalmia, Syndromic 6

MCOPS6

Microphthalmia And Pituitary Anomalies

Microphthalmia With Brain And Digit Anomalies

Microphthalmia With Brain And Digit Developmental Anomalies

Syndromic Microphthalmia Type 6

Syndromic Microphthalmia 6

Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia

Bakrania-Ragge Syndrome

Orofacial Cleft 11

Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia

Microphthalmia Syndromic 6

Microphthalmia, Syndromic, 6

Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia

Microphthalmia Syndromic, Type 6
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation

Epidermolysis Bullosa Simplex With Mottled Pigmentation

Ebsmp

Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering

Ebs-Mp

EBS2F

Ebs With Mottled Pigmentation

Epidermolysis Bullosa Simplex-Mp

Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering

Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Dermatopathia Pigmentosa Reticularis

DPR
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency

CSID

Si Deficiency

Congenital Sucrose Intolerance

Disaccharide Intolerance

Sucrase-Isomaltase Deficiency

Disaccharide Intolerance I

Congenital Sucrose-Isomaltose Malabsorption

Sucrose-Isomaltose Malabsorption, Congenital

Sucrose Intolerance, Congenital

Congenital Sucrase-Isomaltose Malabsorption

Congenital Sucrose-Isomaltase Malabsorption

Disaccharide Intolerance, 1

Sucrose Intolerance Congenital

Sucrose-Isomaltase Malabsorption, Congenital

Disaccharidase Deficiency

Invertase Deficiency

Sucrase-Alpha-Dextrinase Deficiency

Disaccharide Intolerance Type I

Csid - [Congenital Sucrase-Isomaltase Deficiency]

Sucrose Intolerance Of Newborn

Sucrose Intolerance

Sucrase Deficiency

Disaccharide Malabsorption

Intestinal Disaccharidase Deficiency
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Hypotrichosis 2

HYPT2

Hypotrichosis Simplex Of The Scalp 1

Htss1

Htss

Hypotrichosis, Spanish Type

Spanish Type Hypotrichosis

Hypotrichosis Spanish Type

Hypotrichosis, Type 2

Hypotrichosis Simplex Of Scalp
Familial Woolly Hair Syndrome

Wooly Hair

Familial Wooly Hair Syndrome

Hereditary Woolly Hair Syndrome

Hereditary Wooly Hair Syndrome

Woolly Hair

Syndrome With Woolly Hair

Wooly Hair Syndrome
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia

Hed

Anhidrotic Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohidrotic

Eda

Christ-Siemens-Touraine Syndrome

ECTD10B

Ectodermal Dysplasia Anhidrotic

Ectodermal Dysplasia, Anhidrotic

Cst Syndrome

Ectodermal Dysplasia Hypohidrotic Autosomal Recessive

Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive

Dysplasia, Ectodermal, Hypohidrotic

Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Ectodermal Dysplasia 3, Anhidrotic

Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07471 KRT86 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KRT86 MGD MGI:109362
Rattus norvegicus KRT86 RGD RGD:1303215
Macaca mulatta KRT86 VGNC VGNC:107243