2. Gene
  3. Cd274 - CD274 molecule Gene

Cd274 - CD274 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pdcd1lg1; RGD1566211

Gene ID: 499342 | Gene type: protein coding

About Cd274

Primary_assembly 1: 227,116,649-227,134,450 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 102 orthologues, 8 paralogues and is associated with 55 phenotypes. Biased expression in Thymus (RPKM 12.9), Spleen (RPKM 58.3) and 9 other tissues.

Summary

Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd274 Products(1)

mRNA Protein Name
NM_001191954.2 NP_001178883.1 programmed cell death 1 ligand 1 precursor

Cd274 Protein Structure

Ig

Ig: cl11960 (20 - 129)

Ig

Ig: cd00096 (35 - 39)

Ig

Ig: cd00096 (53 - 57)

Ig

Ig: cd00096 (96 - 100)

Ig

Ig: cd00096 (110 - 115)

Ig

Ig: cd00096 (122 - 125)

Ig

Ig: cl11960 (137 - 216)

Ig

Ig: cd00096 (149 - 153)

Ig

Ig: cd00096 (162 - 166)

Ig

Ig: cd00096 (193 - 197)

Ig

Ig: cd00096 (204 - 209)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

programmed cell death 1 ligand 1

Recombinant Cd274 Proteins

Cat. No. Product Name Accession Purity
HY-P70814 PD-L1 Protein, Rat (221a.a, HEK293, His) D4AE25 (A18-T238) ≥95%
HY-P73364 PD-L1 Protein, Rat (HEK293, Fc) NP_001178883.1 (A18-T238) ≥95%
HY-P73365 PD-L1 Protein, Rat (HEK293, His) NP_001178883.1 (A18-T238) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990014 Danburstotug Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02217 CD274 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02218 Cd274 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02219 Cd274 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-14243 CEP-14083 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990757 Ragistomig / Unkown
HY-P990738 Enristomig / Unkown
HY-P990778 Xirestomig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd274 NCBI NCBI:29126
Canis familiaris Cd274 NCBI NCBI:484186
Macaca fascicularis Cd274 NCBI NCBI:102145573
Mus musculus Cd274 NCBI NCBI:60533
Macaca mulatta Cd274 NCBI NCBI:716043