Cd274 - CD274 antigen Gene

Mus musculus

Also known as B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

Gene ID: 60533 | Gene type: protein coding

About Cd274

Chromosome 19: 29,344,855-29,365,495 forward strand.GRCm39:CM001012.3

This gene has 1 transcript (splice variant), 102 orthologues, 8 paralogues and is associated with 41 phenotypes. Broad expression in thymus adult (RPKM 7.4), mammary gland adult (RPKM 5.3) and 23 other tissues.

Summary

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During Infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]

Cd274 Products(2)

mRNA	Protein	Name
NM_021893.3	NP_068693.1	programmed cell death 1 ligand 1 precursor
NM_021893.3	NP_068693.1	programmed cell death 1 ligand 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15568026	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	17016562	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15568026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd274 Protein Structure

IgV_PDl1

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

programmed cell death 1 ligand 1

B7 homolog 1

PDCD1 ligand 1

Cd274 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cd274	Q9EP73	Pdcd1	Mus musculus	Q02242	SPR	23417675
Intra	Cd274	Q9EP73	Cd80	Mus musculus	Q00609	SPR	23417675

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd274 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70632	PD-L1 Protein, Mouse (HEK293, His)	Q9EP73 (F19-T238)	≥95%
HY-P70633	PD-L1 Protein, Mouse (HEK293, Fc)	Q9EP73 (F19-T238)	≥95%
HY-P73716	PD-L1 Protein, Mouse (HEK293, His-Fc)	Q9EP73 (F19-T238)	≥95%
HY-P77819	PD-L1 Protein, Mouse (Biotinylated, HEK293, His)	Q9EP73 (F19-T238)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99698	Lesabelimab	Inhibitor	97.34%	Phase 2
HY-P990014	Danburstotug	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02217	CD274 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02218	Cd274 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02219	Cd274 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14243	CEP-14083	Inhibitor	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990623	MDX-1105	Inhibitor	/	Unkown
HY-P990757	Ragistomig		/	Unkown
HY-P990899	Amostomig		/	Unkown
HY-P991004	Itanistomig		/	Unkown
HY-P991023	Safimestomig		/	Unkown
HY-P991024	Solabafusp alfa	Inhibitor	/	Unkown
HY-P990738	Enristomig		/	Unkown
HY-P990778	Xirestomig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd274	NCBI	NCBI:29126
Canis familiaris	Cd274	NCBI	NCBI:484186
Macaca fascicularis	Cd274	NCBI	NCBI:102145573
Rattus norvegicus	Cd274	NCBI	NCBI:499342
Macaca mulatta	Cd274	NCBI	NCBI:716043

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