P2RY4 - pyrimidinergic receptor P2Y4 Gene

Homo sapiens

Also known as NRU; P2P; UNR; P2Y4

Gene ID: 5030 | Gene type: protein coding

About P2RY4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,258,166-70,260,204 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 15 paralogues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

P2RY4 Products(1)

mRNA	Protein	Name
NM_002565.4	NP_002556.1	P2Y purinoceptor 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY4 Protein Structure

7tm_1

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 4

pyrimidinergic receptor P2Y, G-protein coupled, 4

uridine nucleotide receptor

Related Diseases

Diseases

Alias

Desmoid Disease, Hereditary

Fif	DESMD
Hereditary Desmoid Disease	Familial Infiltrative Fibromatosis
Fibromatosis, Familial Infiltrative	Fibromatosis, Aggressive

Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09931	P2RY4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09932	P2ry4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09933	P2ry4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	P2RY4	VGNC	VGNC:75739
Bos taurus	P2RY4	VGNC	VGNC:32529
Rattus norvegicus	P2RY4	RGD	RGD:61798
Mus musculus	P2RY4	MGD	MGI:1926594
Felis catus	P2RY4	VGNC	VGNC:68675

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