P2RY6 - pyrimidinergic receptor P2Y6 Gene

Homo sapiens

Also known as P2Y6

Gene ID: 5031 | Gene type: protein coding

About P2RY6

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,264,506-73,298,625 (from NCBI)

This gene has 16 transcripts (splice variants), 183 orthologues and 15 paralogues. Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues.

Summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

P2RY6 Products(17)

mRNA	Protein	Name
XM_047427039.1	XP_047282995.1	P2Y purinoceptor 6 isoform X3
XM_047427037.1	XP_047282993.1	P2Y purinoceptor 6 isoform X3
NM_176797.3	NP_789767.1	P2Y purinoceptor 6 isoform 1
XM_011545076.3	XP_011543378.1	P2Y purinoceptor 6 isoform X1
XM_005274022.4	XP_005274079.1	P2Y purinoceptor 6 isoform X3
NM_001277206.2	NP_001264135.1	P2Y purinoceptor 6 isoform 1
XM_011545079.3	XP_011543381.1	P2Y purinoceptor 6 isoform X3
NM_001277208.1	NP_001264137.1	P2Y purinoceptor 6 isoform 2
NM_001277204.2	NP_001264133.1	P2Y purinoceptor 6 isoform 1
NM_176796.3	NP_789766.1	P2Y purinoceptor 6 isoform 1
XM_047427036.1	XP_047282992.1	P2Y purinoceptor 6 isoform X2
NM_001277207.2	NP_001264136.1	P2Y purinoceptor 6 isoform 1
XM_006718571.4	XP_006718634.1	P2Y purinoceptor 6 isoform X3
XM_047427038.1	XP_047282994.1	P2Y purinoceptor 6 isoform X3
NM_001277205.2	NP_001264134.1	P2Y purinoceptor 6 isoform 1
NM_004154.3
NM_176798.2	NP_789768.1	P2Y purinoceptor 6 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled ADP receptor activity	IDA IDA: Inferred from direct assay	8670200	GOA
enables G protein-coupled UDP receptor activity	IDA IDA: Inferred from direct assay	8670200	GOA
enables G protein-coupled UTP receptor activity	IDA IDA: Inferred from direct assay	8670200	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to purine-containing compound	IDA IDA: Inferred from direct assay	8670200	GOA
involved in cellular response to pyrimidine ribonucleotide	IDA IDA: Inferred from direct assay	8670200	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	28277742	GOA
involved in positive regulation of inositol trisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	8670200	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28277742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY6 Protein Structure

7tm_1

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 6

G-coupled nucleotide receptor	P2 purinoceptor
P2Y6 receptor	pyrimidinergic receptor P2Y, G-protein coupled, 6

P2RY6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	P2RY6	Q15077	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	P2RY6	Q15077	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	P2RY6	Q15077	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	P2RY6	Q15077	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	P2RY6	Q15077	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	P2RY6	Q15077	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	P2RY6	Q15077	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	P2RY6	Q15077	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	P2RY6	Q15077	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	MCFD2	Homo sapiens	Q8NI22	Validated Y2H	32296183
Intra	P2RY6	Q15077	CSE1L	Homo sapiens	P55060	Pull Down	30833792
Intra	P2RY6	Q15077	KPNB1	Homo sapiens	Q14974	Pull Down	30833792
Intra	P2RY6	Q15077	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	P2RY6	Q15077	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	P2RY6	Q15077	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	P2RY6	Q15077	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	P2RY6	Q15077	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	P2RY6	Q15077	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	P2RY6	Q15077	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	P2RY6	Q15077	PLSCR1	Homo sapiens	O15162	Validated Y2H	25416956
Intra	P2RY6	Q15077	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	P2RY6	Q15077	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09934	P2RY6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09935	P2ry6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09936	P2ry6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	P2RY6	RGD	RGD:620269
Canis familiaris	P2RY6	VGNC	VGNC:44218
Bos taurus	P2RY6	VGNC	VGNC:32530
Mus musculus	P2RY6	MGD	MGI:2673874
Macaca mulatta	P2RY6	VGNC	VGNC:75740
Felis catus	P2RY6	VGNC	VGNC:81964

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