CSE1L - chromosome segregation 1 like Gene

Homo sapiens

Also known as CAS; CSE1; XPO2

Gene ID: 1434 | Gene type: protein coding

About CSE1L

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,046,312-49,096,949 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and 4 paralogues. Broad expression in testis (RPKM 57.6), esophagus (RPKM 21.5) and 24 other tissues.

Summary

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in Apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CSE1L Products(3)

mRNA	Protein	Name
NM_001256135.2	NP_001243064.1	exportin-2 isoform 2
NM_001316.4	NP_001307.2	exportin-2 isoform 1
NM_001362762.2	NP_001349691.1	exportin-2 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17719542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSE1L Protein Structure

IBN_N

Cse1

CAS_CSE1

0
200
400
600
800
971 a.a.

Protein Preferred Names

Protein Names

exportin-2

CSE1 chromosome segregation 1-like

CSE1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSE1L	P55060	VAMP5	Homo sapiens	O95183	Pull Down	30833792
Intra	CSE1L	P55060	P2RY6	Homo sapiens	Q15077	Pull Down	30833792
Intra	CSE1L	P55060	MS4A4A	Homo sapiens	Q96JQ5	Pull Down	30833792
Intra	CSE1L	P55060	TP53	Homo sapiens	P04637	Anti Bait CoIP	17719542
Intra	CSE1L	P55060	TP53	Homo sapiens	P04637	Crosslink	17719542
Intra	CSE1L	P55060	UNC93B1	Homo sapiens	Q9H1C4	Pull Down	30833792
Intra	CSE1L	P55060	TNFSF13B	Homo sapiens	Q9Y275	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

CSE1L Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82519	Cellular Apoptosis Susceptibility Antibody (YA2264)	WB, IHC-P, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03226	CSE1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSE1L	RGD	RGD:1307536
Felis catus	CSE1L	VGNC	VGNC:80076
Bos taurus	CSE1L	VGNC	VGNC:27752
Macaca mulatta	CSE1L	VGNC	VGNC:71512
Canis familiaris	CSE1L	VGNC	VGNC:39651
Mus musculus	CSE1L	MGD	MGI:1339951

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