2. Gene
  3. LAP3 - leucine aminopeptidase 3 Gene

LAP3 - leucine aminopeptidase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LAP; PEPS; LAPEP; HEL-S-106

Gene ID: 51056 | Gene type: protein coding

About LAP3

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,577,198-17,607,970 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LAP3 Products(1)

mRNA Protein Name
NM_015907.3 NP_056991.2 cytosol aminopeptidase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAP3 Protein Structure

Peptidase_M17_N

Peptidase_M17_N: Cytosol aminopeptidase family, N-terminal domain (37 - 169)

Peptidase_M17

Peptidase_M17: Cytosol aminopeptidase family, catalytic domain (196 - 509)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

cytosol aminopeptidase

cysteinylglycine-S-conjugate dipeptidase

LAP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LAP3 P28838 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Array
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Validated Y2H
32296183
Intra
LAP3 P28838 ZNF76 Homo sapiens P36508
Validated Y2H
32296183
Intra
LAP3 P28838 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Array
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Validated Y2H
32296183
Intra
LAP3 P28838 CBX5 Homo sapiens P45973
Validated Y2H
32296183
Intra
LAP3 P28838 CBX5 Homo sapiens P45973
Y2H Array
32296183
Intra
LAP3 P28838 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAP3 Proteins

Cat. No. Product Name Accession Purity
HY-P74780 LAP3 Protein, Human (HEK293, His) P28838/NP_056991.2 (M1-A519) ≥95%

Related Diseases

Diseases Alias
Bacterial Vaginosis

Vaginosis, Bacterial
Haverhill Fever

Streptobacillosis

Streptobacillary Rat-Bite Fever

Streptobacillary Fever

Rat-Bite Fever Due To Streptobacillus Moniliformis

Erythema Arthriticum Epidemicum

Epidemic Arthritic Erythema
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Syphilitic Meningitis

Syphilitic Aseptic Meningitis

Meningeal Syphilis

Meningitis, Syphilitic
Vaginitis

Infective Vaginitis

Inflammation Of Vagina

Colpitis

Vaginal Inflammation

Vaginitis Nos
Vaginal Disease

Vaginal Diseases
Vaginal Discharge
Specific Language Impairment

Language Impairment, Specific
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137844 L-Leucine-7-amido-4-methylcoumarin hydrochloride 99.17% Unkown
HY-108546 L-AP3 Antagonist / Unkown
HY-RS07520 LAP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LAP3 VGNC VGNC:78519
Mus musculus LAP3 MGD MGI:1914238
Bos taurus LAP3 VGNC VGNC:30786
Macaca mulatta LAP3 VGNC VGNC:97784
Canis familiaris LAP3 VGNC VGNC:42582
Rattus norvegicus LAP3 RGD RGD:1307985
Others LAP3 NCBI