MRNIP - MRN complex interacting protein Gene

Homo sapiens

Also known as C5orf45

Gene ID: 51149 | Gene type: protein coding

About MRNIP

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,837,276-179,858,817 (from NCBI)

This gene has 24 transcripts (splice variants), 1 gene allele and 122 orthologues. Ubiquitous expression in endometrium (RPKM 41.9), lung (RPKM 28.1) and 25 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; regulation of double-strand break repair; and response to ionizing radiation. Located in nucleoplasm. Colocalizes with Mre11 complex. [provided by Alliance of Genome Resources, Apr 2022]

MRNIP Products(2)

mRNA	Protein	Name
NM_001017987.3	NP_001017987.1	MRN complex-interacting protein isoform 2
NM_016175.4	NP_057259.2	MRN complex-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	27568553	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27568553	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27568553	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	27568553	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	27568553	GOA
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	27568553	GOA
involved in protein localization to chromatin	IDA IDA: Inferred from direct assay	27568553	GOA
involved in regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	27568553	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	27568553	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Mre11 complex	IDA IDA: Inferred from direct assay	27568553	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	27568553	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27568553	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MRN complex-interacting protein

MRN-interacting protein

MRNIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRNIP	Q6NTE8	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	MRNIP	Q6NTE8	DUSP23	Homo sapiens	Q9BVJ7	Validated Y2H	32296183
Intra	MRNIP	Q6NTE8	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MRNIP	Q6NTE8	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Complementation Group B

Xeroderma Pigmentosum Group B	Xeroderma Pigmentosum, Group B
XPB	Xpbc
Xp Group B	Xp, Group B
Xeroderma Pigmentosum Complementation Group B	XP-B
Xeroderma Pigmentosum Group B With Cockayne Syndrome	Xeroderma Pigmentosum Ii
Xp2	Xp-B/Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08658	MRNIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MRNIP	VGNC	VGNC:52861
Mus musculus	MRNIP	MGD	MGI:1915317
Felis catus	MRNIP	VGNC	VGNC:63584
Canis familiaris	MRNIP	VGNC	VGNC:56068
Macaca mulatta	MRNIP	VGNC	VGNC:84447
Rattus norvegicus	MRNIP	RGD	RGD:1564036

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