CDK17 - cyclin dependent kinase 17 Gene

Homo sapiens

Also known as PCTK2; PCTAIRE2

Gene ID: 5128 | Gene type: protein coding

About CDK17

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,278,225-96,400,439 (from NCBI)

This gene has 12 transcripts (splice variants), 268 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

CDK17 Products(2)

mRNA	Protein	Name
NM_001170464.4	NP_001163935.1	cyclin-dependent kinase 17 isoform 2
NM_002595.5	NP_002586.2	cyclin-dependent kinase 17 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK17 Protein Structure

Pkinase

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 17

PCTAIRE-motif protein kinase 2

CDK17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK17	Q00537	BICDL2	Homo sapiens	A1A5D9	Y2H Array	32296183
Intra	CDK17	Q00537	BICDL2	Homo sapiens	A1A5D9	Y2H Prey Pooling	32296183
Intra	CDK17	Q00537	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	CDK17	Q00537	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CDK17	Q00537	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CDK17	Q00537	CDK16	Homo sapiens	Q00536	Anti Tag CoIP	33961781
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Y2H Prey Pooling	32296183
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137346	DD-03-156	Degrader	99.63%	Unkown
HY-RS02369	CDK17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDK17	VGNC	VGNC:108225
Felis catus	CDK17	VGNC	VGNC:68736
Macaca mulatta	CDK17	VGNC	VGNC:71161
Rattus norvegicus	CDK17	RGD	RGD:1565593
Mus musculus	CDK17	MGD	MGI:97517
Bos taurus	CDK17	VGNC	VGNC:27120
Others	CDK17	NCBI

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