DACT1 - dishevelled binding antagonist of beta catenin 1 Gene

Homo sapiens

Also known as DPR1; TBS2; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1

Gene ID: 51339 | Gene type: protein coding

About DACT1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,634,061-58,648,321 (from NCBI)

This gene has 6 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 10.6), ovary (RPKM 9.1) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

DACT1 Products(2)

mRNA	Protein	Name
NM_001079520.2	NP_001072988.1	dapper homolog 1 isoform 2
NM_016651.6	NP_057735.2	dapper homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	18936100	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16446366	GOA
enables protein kinase A binding	IDA IDA: Inferred from direct assay	21262972	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	18936100	GOA
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	17197390	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16446366	GOA
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16446366	GOA
involved in negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18936100	GOA
involved in negative regulation of beta-catenin-TCF complex assembly	IDA IDA: Inferred from direct assay	18936100	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18936100	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22610794	GOA
involved in negative regulation of protein binding	IGI IGI: Inferred from genetic interaction	18936100	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18936100	GOA
involved in neural tube development	IMP IMP: Inferred from mutant phenotype	22610794	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	21262972	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15580286	GOA
involved in positive regulation of protein binding	IGI IGI: Inferred from genetic interaction	18936100	GOA
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16446366	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16446366	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	18936100	GOA
involved in regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18936100	GOA
NOT involved in regulation of nodal signaling pathway	IDA IDA: Inferred from direct assay	17197390	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	21262972	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	22470507	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16446366	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18936100	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACT1 Protein Structure

Dapper

0
200
400
600
836 a.a.

Protein Preferred Names

Protein Names

dapper homolog 1

dapper antagonist of catenin 1

DACT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DACT1	Q9NYF0	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	22470507
Intra	DACT1	Q9NYF0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22470507
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Imaging	16446366
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Anti Bait CoIP	16446366
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Anti Tag CoIP	16446366

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Townes-Brocks Syndrome 2

TBS2

Craniorachischisis

Anencephaly With Rachischisis

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Occipital Encephalocele

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Myelomeningocele

Meningomyelocele

Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness

Multiple Epiphyseal Dysplasia, Beighton Type	EDMMD
Epiphyseal Dysplasia, Multiple, With Myopia And Deafness	Multiple Epiphyseal Dysplasia With Myopia And Deafness
Multiple Epiphyseal Dysplasia-Myopia-Deafness Syndrome	Multiple Epiphyseal Dysplasia-Myopia-Hearing Loss Syndrome
Multiple Epiphyseal Dysplasia With Myopia And Conductive Deafness	Dysplasia, Epiphyseal, Multiple, With Myopia And Deafness

Intestinal Disaccharidase Deficiency

Disaccharidase Deficiency

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Orange Allergy

Citrus Sinensis Fruit Allergy

Deafness, Autosomal Recessive 100

DFNB100	Autosomal Recessive Nonsyndromic Deafness 100
Autosomal Recessive Deafness 100	Deafness, Autosomal Recessive, 100

Ectodermal Dysplasia 5, Hair/Nail Type

ECTD5

Ectodermal Dysplasia 5

Ectodermal Dysplasia 6, Hair/Nail Type

ECTD6

Ectodermal Dysplasia 6

Ectodermal Dysplasia 7, Hair/Nail Type

ECTD7	Ectodermal Dysplasia 7
Dysplasia, Ectodermal, Type 7, Hair/Nail

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency

17-Ksr Deficiency	Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency
Pseudohermaphroditism, Male, With Gynecomastia	17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency
Testosterone 17-Beta-Dehydrogenase Deficiency	17-Ketosteroid Reductase Deficiency Of Testis
17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency	17-Ketoreductase Deficiency
17-Ketosteroidreductase Deficiency	46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency
Male Pseudohermaphroditism With Gynecomastia	17 Alpha Ksr Deficiency
17 Alpha Ketosteroid Reductase Deficiency Of Testis	17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency
Male Pseudoherma-Phroditism With Gynecomastia	Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency
Male Pseudohermaphrodism With Gynecomastia	MPH
17-Hydroxysteroid Dehydrogenase Deficiency

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03515	DACT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DACT1	MGD	MGI:1891740
Bos taurus	DACT1	VGNC	VGNC:27867
Felis catus	DACT1	VGNC	VGNC:104383
Canis familiaris	DACT1	VGNC	VGNC:39761
Macaca mulatta	DACT1	VGNC	VGNC:71650
Rattus norvegicus	DACT1	RGD	RGD:1564008

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