PDE3A - phosphodiesterase 3A Gene

Homo sapiens

Also known as HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A

Gene ID: 5139 | Gene type: protein coding

About PDE3A

Cytogenetic location: 12p12.2 Genomic coordinates (GRCh38): 12:20,368,537-20,688,583 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 15.7), placenta (RPKM 7.2) and 17 other tissues.

Summary

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE Enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

PDE3A Products(5)

mRNA	Protein	Name
NM_001378407.1	NP_001365336.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 3
NM_001244683.2	NP_001231612.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 2
NM_000921.5	NP_000912.3	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1
NM_001378408.1	NP_001365337.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 4
NM_001378409.1	NP_001365338.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	27975297	GOA
enables estrogen binding	IDA IDA: Inferred from direct assay	31420216	GOA
enables nuclear estrogen receptor activity	IDA IDA: Inferred from direct assay	31420216	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19332778	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	31420216	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	31420216	GOA
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cellular response to cGMP	IDA IDA: Inferred from direct assay	17704206	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	17704206	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252089	GOA
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in regulation of ribonuclease activity	IDA IDA: Inferred from direct assay	34272366	GOA
involved in regulation of ribonuclease activity	IMP IMP: Inferred from mutant phenotype	35104454	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	35104454	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE3A Protein Structure

PDEase_I

0
200
400
600
800
1000
1141 a.a.

Protein Preferred Names

Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

cAMP phosphodiesterase, myocardial cGMP-inhibited	cGMP-inhibited 3',5'-cyclic phosphodiesterase A
cGMP-inhibited cAMP phosphodiesterase	cyclic GMP-inhibited phosphodiesterase A
phosphodiesterase 3A, cGMP-inhibited

Recombinant PDE3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75961	PDE3A Protein, Human (sf9, His-GST)	Q14432 (K669-Q1141)	≥95%

Related Diseases

Diseases

Alias

Brachydactyly

Osseous Heteroplasia, Progressive

Progressive Osseous Heteroplasia	POH
Osteoma Cutis	Familial Ectopic Ossification
Ectopic Ossification Familial Type	Ectopic Ossification
Heterotopic Ossification	Ectopic Ossification, Familial
Cutaneous Ossification	Myositis Ossificans Progressiva
Osteodermia	Osteosis Cutis
Ossification Heterotopic	Heteroplasia, Osseous, Progressive
Fibrodysplasia Ossificans Progressiva

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Tooth Ankylosis

Ankylosis Of Teeth

Ankylosis Of Tooth

Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities	Scn8
Sdsl	Shwachman-Diamond Syndrome-Like

Pseudopseudohypoparathyroidism

PPHP	Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance
Normocalcemic Pseudohypoparathyroidism	Aho-Pphp Syndrome
Albright Hereditary Osteodystrophy-Pphp Syndrome	Pseudohypoparathyroidism

Hypertension And Brachydactyly Syndrome

Brachydactyly With Hypertension	Bilginturan Syndrome
HTNB	Brachydactyly-Arterial Hypertension Syndrome
Brachydactyly, Type E, With Short Stature And Hypertension	Bilginturan Brachydactyly
Brachydactyly Type E With Short Stature And Hypertension	Type E Brachydactyly With Short Stature And Hypertension
Brachydactyly Type E, With Short Stature And Hypertension	Hypertension With Brachydactyly

Congestive Heart Failure

Congestive Heart Disease	Heart Failure
Cardiac Failure Congestive	Chf
Weak Heart	Heart Failure Congestive
Ccf - [Congestive Cardiac Failure]	Chf - [Congestive Heart Failure]
Congestive Cardiac Diseases	Congested Heart Failure
Congestive Cardiac Failure	Cardiac Anasarca
Cardiac Oedema	Cardiac Stasis
Cardiovascular Oedema	Cardiac Hydrops
Congestive Failure	Heart Congestion
Heart Fluid	Oedematous Heart

Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy	Albright Hereditary Osteodystrophy
Pseudohypoparathyroidism Type 1a	PHP1A
Albright Hereditary Osteodystrophy With Multiple Hormone Resistance	Pseudohypoparathyroidism Ia
AHO	Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Pseudo-Pseudohypoparathyroidism	Pseudohypoparathyroidism Type I A
Php Ia	Pseudopseudohypoparathyroidism
Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance	Pphp
Pseudopseudo-Hypoparathyroidism	Aho-Php Syndrome Ia
Albright Hereditary Osteodystrophy-Php Syndrome Ia	Pseudohypoparathyroidism 1a
Pseudohypoparathyroidism

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Hypothyroidism, Congenital, Nongoitrous, 1

Tsh Resistance	CHNG1
Hypothyroidism Due To Tsh Receptor Mutations	Thyrotropin Resistance
Rtsh	Hypothyroidism Due To Unresponsiveness To Thyrotropin
Congenital Nongoitrous Hypothyroidism 1	Thyroid-Stimulating Hormone
Thyroid-Stimulating Hormone, Resistance To	Hypothyroidism, Nonautoimmune
Hypothyroidism, Congenital, Due To Tsh Resistance	Hypothyroidism, Congenital, Non-Goitrous, 1
Congenital Hypothyroidism Due To Tsh Resistance	Non-Autoimmune Hypothyroidism
Thyroid-Stimulating Hormone Resistance	Hypothyroidism, Congenital, Nongoitrous, Type 1
Hypothyroidism, Congenital, Nongoitrous, 3	Thyroid Hormone Resistance Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2
HY-U00186	K134	Inhibitor	99.84%	Phase 2
HY-145924	BAY 2666605	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101312	Cilostamide	Inhibitor	99.64%	Unkown
HY-W028690	DNMDP	Inhibitor	98.95%	Unkown
HY-100530C	Sp-cAMPS sodium salt		99.45%	Unkown
HY-136350	BRD9500	Modulator	99.46%	Unkown
HY-122751	(R)-DNMDP	Inhibitor	99.59%	Unkown
HY-100530B	Sp-cAMPS		/	Unkown
HY-136350B	(S)-BRD9500		99.67%	Unkown
HY-110005	Sp-cAMPS triethylamine		/	Unkown
HY-153802	Antitumor agent-100	Inducer	/	Unkown
HY-153802A	Antitumor agent-100 hydrochloride	Inducer	/	Unkown
HY-162730	OPB-171775	Inhibitor	99.80%	Unkown
HY-N10149	Nauclefine		/	Unkown
HY-N11965	4'-Methoxyisoagarotetrol	Inhibitor	/	Unkown
HY-RS10216	PDE3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10217	Pde3a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10218	Pde3a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDE3A	VGNC	VGNC:54467
Macaca mulatta	PDE3A	VGNC	VGNC:75913
Canis familiaris	PDE3A	VGNC	VGNC:44352
Felis catus	PDE3A	VGNC	VGNC:68756
Mus musculus	PDE3A	MGD	MGI:1860764
Rattus norvegicus	PDE3A	RGD	RGD:61942
Others	PDE3A	NCBI

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