2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues Phosphodiesterase (PDE)
  4. OPB-171775

OPB-171775 is a molecular glue, which forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway, and exhibits antitumor efficacy.

For research use only. We do not sell to patients.

OPB-171775 Chemical Structure

OPB-171775 Chemical Structure

CAS No. : 2131210-15-4

Size Price Stock Quantity
5 mg USD 195 In-stock
10 mg USD 295 In-stock
25 mg USD 495 In-stock
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Based on 1 publication(s) in Google Scholar

OPB-171775 Related Antibodies

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Description

OPB-171775 is a molecular glue, which forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway, and exhibits antitumor efficacy[1].

Molecular Weight

312.31

Formula

C15H18F2N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C([C@H](C)C2)=NNC2=O)C=CC(OCC(O)(C)C)=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (400.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2019 mL 16.0097 mL 32.0195 mL
5 mM 0.6404 mL 3.2019 mL 6.4039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2019 mL 16.0097 mL 32.0195 mL 80.0487 mL
5 mM 0.6404 mL 3.2019 mL 6.4039 mL 16.0097 mL
10 mM 0.3202 mL 1.6010 mL 3.2019 mL 8.0049 mL
15 mM 0.2135 mL 1.0673 mL 2.1346 mL 5.3366 mL
20 mM 0.1601 mL 0.8005 mL 1.6010 mL 4.0024 mL
25 mM 0.1281 mL 0.6404 mL 1.2808 mL 3.2019 mL
30 mM 0.1067 mL 0.5337 mL 1.0673 mL 2.6683 mL
40 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0012 mL
50 mM 0.0640 mL 0.3202 mL 0.6404 mL 1.6010 mL
60 mM 0.0534 mL 0.2668 mL 0.5337 mL 1.3341 mL
80 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0006 mL
100 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8005 mL
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OPB-171775 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OPB-1717752131210-15-4OPB171775OPB 171775Molecular GluesPhosphodiesterase (PDE)PFSK-1HeLaGIST-T1NCI-H2122gastrointestinal stromal tumorInhibitorinhibitorinhibit

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