2. Gene
  3. FAM8A1 - family with sequence similarity 8 member A1 Gene

FAM8A1 - family with sequence similarity 8 member A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AHCP

Gene ID: 51439 | Gene type: protein coding

About FAM8A1

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:17,600,302-17,611,715 (from NCBI)

This gene has 7 transcripts (splice variants) and 263 orthologues. Ubiquitous expression in liver (RPKM 21.6), endometrium (RPKM 17.3) and 25 other tissues.

Summary

Predicted to be involved in ubiquitin-dependent ERAD pathway. Part of Hrd1p ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

FAM8A1 Products(1)

mRNA Protein Name
NM_016255.3 NP_057339.1 protein FAM8A1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22119785 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Hrd1p ubiquitin ligase complex IDA
IDA: Inferred from direct assay
28827405 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM8A1 Protein Structure

RDD

RDD: RDD family (243 - 403)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

protein FAM8A1

Autosomal Highly Conserved Protein

FAM8A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FAM8A1 Q9UBU6 SYVN1 Homo sapiens Q86TM6
Anti Bait CoIP
22119785
Intra
FAM8A1 Q9UBU6 SYVN1 Homo sapiens Q86TM6
Anti Tag CoIP
33961781
Intra
FAM8A1 Q9UBU6 SYVN1 Homo sapiens Q86TM6
Affinity Chrom
28827405
Intra
FAM8A1 Q9UBU6 SYVN1 Homo sapiens Q86TM6
Pull Down
22119785
Intra
FAM8A1 Q9UBU6 SYVN1 Homo sapiens Q86TM6
Confocal
22119785
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04728 FAM8A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FAM8A1 MGD MGI:2145496
Rattus norvegicus FAM8A1 RGD RGD:1307845
Canis familiaris FAM8A1 VGNC VGNC:40709
Bos taurus FAM8A1 VGNC VGNC:28844
Macaca mulatta FAM8A1 VGNC VGNC:72277
Felis catus FAM8A1 VGNC VGNC:102422