RNF138 - ring finger protein 138 Gene

Homo sapiens

Also known as NARF; HSD-4; STRIN; hNARF

Gene ID: 51444 | Gene type: protein coding

About RNF138

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,091,874-32,131,561 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 4 paralogues. Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues.

Summary

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNF138 Products(3)

mRNA	Protein	Name
NM_001191324.2	NP_001178253.2	E3 ubiquitin-protein ligase RNF138 isoform 1
NM_016271.5	NP_057355.2	E3 ubiquitin-protein ligase RNF138 isoform 1
NM_198128.3	NP_937761.1	E3 ubiquitin-protein ligase RNF138 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16714285	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	26502055	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	26502055	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA double-strand break processing involved in repair via single-strand annealing	IMP IMP: Inferred from mutant phenotype	26502057	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	26502055	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	26502055	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in site of double-strand break	IDA IDA: Inferred from direct assay	26502055	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF138 Protein Structure

zf-C3HC4

zf-Di19

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF138

NLK-associated RING finger protein

RNF138 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF138	Q8WVD3	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RNF138	Q8WVD3	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RNF138	Q8WVD3	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	RNF138	Q8WVD3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RNF138	Q8WVD3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	RNF138	Q8WVD3	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RNF138	Q8WVD3	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RNF138	Q8WVD3	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	RNF138	Q8WVD3	UBE2K	Homo sapiens	P61086	Y2H	19549727
Intra	RNF138	Q8WVD3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RNF138	Q8WVD3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	RNF138	Q8WVD3	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RNF138	Q8WVD3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RNF138	Q8WVD3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RNF138	Q8WVD3	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12050	RNF138 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF138	RGD	RGD:621485
Mus musculus	RNF138	MGD	MGI:1929211
Felis catus	RNF138	VGNC	VGNC:80479
Canis familiaris	RNF138	VGNC	VGNC:45631
Macaca mulatta	RNF138	VGNC	VGNC:76755
Bos taurus	RNF138	VGNC	VGNC:34022

Name
Email *

	Sorry, but the email address you supplied was invalid.