RTCB - RNA 2',3'-cyclic phosphate and 5'-OH ligase Gene

Homo sapiens

Also known as FAAP; HSPC117; C22orf28; DJ149A16.6

Gene ID: 51493 | Gene type: protein coding

About RTCB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,387,582-32,412,247 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in duodenum (RPKM 45.6), small intestine (RPKM 40.2) and 25 other tissues.

Summary

Enables RNA Ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTCB Products(1)

mRNA	Protein	Name
NM_014306.5	NP_055121.1	RNA-splicing ligase RtcB homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA ligase (GTP) activity	IDA IDA: Inferred from direct assay	21311021	GOA
enables RNA ligase (GTP) activity	IMP IMP: Inferred from mutant phenotype	24870230	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24608264	GOA
enables vinculin binding	IPI IPI: Inferred from physical interaction	15163412	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA splicing, via endonucleolytic cleavage and ligation	IDA IDA: Inferred from direct assay	21311021	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24608264	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24608264	GOA
part of tRNA-splicing ligase complex	IDA IDA: Inferred from direct assay	21311021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTCB Protein Structure

RtcB

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

RNA-splicing ligase RtcB homolog

3'-phosphate/5'-hydroxy nucleic acid ligase

RTCB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTCB	Q9Y3I0	RTRAF	Homo sapiens	Q9Y224	TAP	24608264
Intra	RTCB	Q9Y3I0	RTRAF	Homo sapiens	Q9Y224	Pull Down	30833792
Intra	RTCB	Q9Y3I0	RTRAF	Homo sapiens	Q9Y224	Anti Tag CoIP	35271311
Intra	RTCB	Q9Y3I0	APPL1	Homo sapiens	Q9UKG1	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oropharyngeal Anthrax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145675A	(R)-TCB2		/	Unkown
HY-RS12316	RTCB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RTCB	VGNC	VGNC:34194
Macaca mulatta	RTCB	VGNC	VGNC:77111
Mus musculus	RTCB	MGD	MGI:106379
Felis catus	RTCB	VGNC	VGNC:64805
Rattus norvegicus	RTCB	RGD	RGD:1303261
Canis familiaris	RTCB	VGNC	VGNC:49844

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