GSKIP - GSK3B interacting protein Gene

Homo sapiens

Also known as HSPC210; C14orf129

Gene ID: 51527 | Gene type: protein coding

About GSKIP

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,363,526-96,387,290 (from NCBI)

This gene has 7 transcripts (splice variants) and 209 orthologues. Broad expression in colon (RPKM 25.5), small intestine (RPKM 20.7) and 24 other tissues.

Summary

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-Cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GSKIP Products(4)

mRNA	Protein	Name
NM_001271904.1	NP_001258833.1	GSK3B-interacting protein
NM_001271905.2	NP_001258834.1	GSK3B-interacting protein
NM_001271906.2	NP_001258835.1	GSK3B-interacting protein
NM_016472.5	NP_057556.2	GSK3B-interacting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables beta-catenin binding	IDA IDA: Inferred from direct assay	27484798	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20007971	GOA
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	20007971	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	27484798	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16981698	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	19830702	GOA
enables protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	16981698	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	25920809	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	16981698	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	27484798	GOA
involved in regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16981698	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16981698	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20007971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSKIP Protein Structure

DUF727

0
100
139 a.a.

Protein Preferred Names

Protein Names

GSK3B-interacting protein

GSK3-beta interaction protein

GSKIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GSKIP	Q9P0R6	GSK3A	Homo sapiens	P49840	Anti Tag CoIP	33961781
Intra	GSKIP	Q9P0R6	GSK3A	Homo sapiens	P49840	Y2H Pooling	20368287

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 20

Diabetes Mellitus, Insulin-Dependent, 20	IDDM20
T1D20	Insulin-Dependent Diabetes Mellitus 20
Diabetes Mellitus, Insulin-Dependent, Type 20

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05866	GSKIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GSKIP	VGNC	VGNC:29679
Mus musculus	GSKIP	MGD	MGI:1914037
Canis familiaris	GSKIP	VGNC	VGNC:41531
Rattus norvegicus	GSKIP	RGD	RGD:1308470
Felis catus	GSKIP	VGNC	VGNC:80960
Macaca mulatta	GSKIP	VGNC	VGNC:73202

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