2. Gene
  3. IL23A - interleukin 23 subunit alpha Gene

IL23A - interleukin 23 subunit alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P19; SGRF; IL-23; IL-23A; IL23P19

Gene ID: 51561 | Gene type: protein coding

About IL23A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,338,884-56,340,410 (from NCBI)

This gene has 3 transcripts (splice variants) and 96 orthologues. Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues.

Summary

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

IL23A Products(1)

mRNA Protein Name
NM_016584.3 NP_057668.1 interleukin-23 subunit alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to interleukin-23 receptor binding IDA
IDA: Inferred from direct assay
11114383 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11114383 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
12023369 GOA
involved in cell surface receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
19088061 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
15114670 GOA
involved in negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16751425 GOA
involved in positive regulation of NK T cell activation IDA
IDA: Inferred from direct assay
19088061 GOA
involved in positive regulation of NK T cell proliferation IDA
IDA: Inferred from direct assay
19088061 GOA
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12023369 GOA
involved in positive regulation of T-helper 1 type immune response IDA
IDA: Inferred from direct assay
15114670 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: Inferred from direct assay
11114383 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
12421946 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
20027291 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
15265908 GOA
involved in positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
20027291 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: Inferred from direct assay
16482511 GOA
involved in positive regulation of natural killer cell proliferation IDA
IDA: Inferred from direct assay
19088061 GOA
involved in positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
17888176 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16751425 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11114383 GOA
Cellular Component GO Annotation Evidence Reference Source
part of interleukin-23 complex IDA
IDA: Inferred from direct assay
11114383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL23A Protein Structure

IL6

IL6: Interleukin-6/G-CSF/MGF family (66 - 179)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

interleukin-23 subunit alpha

IL-23 subunit alpha

IL-23-A

IL-23p19

JKA3 induced upon T-cell activation

interleukin 23 p19 subunit

interleukin 23, alpha subunit p19

interleukin-23 subunit p19

interleukin-six, G-CSF related factor

IL23A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL23A Q9NPF7 IL23R Homo sapiens Q5VWK5
Anti Tag CoIP
12023369
Intra
IL23A Q9NPF7 IL12B Homo sapiens P29460
X-Ray Diffraction
18680750
Intra
IL23A Q9NPF7 IL12B Homo sapiens P29460
Anti Tag CoIP
12023369
Intra
IL23A Q9NPF7 IL12B Homo sapiens P29460
Anti Tag CoIP
11114383
Intra
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Validated Y2H
25416956
Intra
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Y2H Prey Pooling
32296183
Intra
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL23A Proteins

Cat. No. Product Name Accession Purity
HY-P70736 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, C-His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P73193 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P74816 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P74874 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P76432 IL-23 alpha Protein, Human (HEK293, Fc) Q9NPF7 (R20-P189) ≥95%
HY-P77704 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P77712 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P700114AF Animal-Free IL-23 alpha Protein, Human (His) Q9NPF7 (R20-P189) ≥95%

Related Diseases

Diseases Alias
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Psoriasis
Hidradenitis

Hydradenitis
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To
Autoimmune Disease Of Skin And Connective Tissue
Autoimmune Cholangitis

Autoimmune Cholangiopathy
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Enteritis, Granulomatous

Crohn'S Disease Of Colon

Granulomatous Colitis

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Enteritis

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Colitis
Erythema Nodosum
Hidradenitis Suppurativa

Acne Inversa

Suppurative Hidradenitis

Acne Inversa, Familial

Apocrinitis

Hidradenitides, Suppurative

Hidradenitis, Suppurative

Suppurative Hidradenitides

Inverse Acne
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis
Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Spondylitis
Gastroenteritis

Cholera Morbus

Infectious Colitis, Enteritis And Gastroenteritis

Enteritis Due To Astrovirus

Rotaviral Gastroenteritis

Viral Gastroenteritis Due To Rotavirus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06739 IL23A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06740 Il23a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06741 Il23a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990057 Picankibart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL23A MGD MGI:1932410
Bos taurus IL23A VGNC VGNC:30146
Canis familiaris IL23A VGNC VGNC:41972
Felis catus IL23A VGNC VGNC:62907
Macaca mulatta IL23A VGNC VGNC:73601
Rattus norvegicus IL23A RGD RGD:620873
Others IL23A NCBI