METTL13 - methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Gene

Homo sapiens

Also known as feat; DFNM1; CGI-01; DFNB26; DFNB26M; KIAA0859; EEF1AKNMT; 5630401D24Rik

Gene ID: 51603 | Gene type: protein coding

About METTL13

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,781,660-171,797,716 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 10.7), lymph node (RPKM 7.3) and 25 other tissues.

Summary

Predicted to enable methyltransferase activity. Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL13 Products(3)

mRNA	Protein	Name
NM_001007239.2	NP_001007240.1	eEF1A lysine and N-terminal methyltransferase isoform 3
NM_014955.3	NP_055770.1	eEF1A lysine and N-terminal methyltransferase isoform 2
NM_015935.5	NP_057019.3	eEF1A lysine and N-terminal methyltransferase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	30143613	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL13 Protein Structure

Methyltransf_11

Methyltransf_18

0
200
400
600
699 a.a.

Protein Preferred Names

Protein Names

eEF1A lysine and N-terminal methyltransferase

antiapoptotic protein FEAT

METTL13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL13	Q8N6R0	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	METTL13	Q8N6R0	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	METTL13	Q8N6R0	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	METTL13	Q8N6R0	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	METTL13	Q8N6R0	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	METTL13	Q8N6R0	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	METTL13	Q8N6R0	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	METTL13	Q8N6R0	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	METTL13	Q8N6R0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	METTL13	Q8N6R0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	METTL13	Q8N6R0	SNRPA	Homo sapiens	P09012	Validated Y2H	25416956
Intra	METTL13	Q8N6R0	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	25416956
Intra	METTL13	Q8N6R0	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	METTL13	Q8N6R0	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	METTL13	Q8N6R0	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	METTL13	Q8N6R0	THAP1	Homo sapiens	Q9NVV9	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 26, Modifier Of

Deafness, Nonsyndromic, Modifier 1	DFNB26M
Dfnb26, Modifier Of	Dfnb26, Suppressor Of
Deafness, Nonsyndromic, Modifier Of, 1	Dfnm1
{Deafness, Autosomal Recessive 26, Modifier Of}

Autosomal Dominant Nonsyndromic Deafness 74

Dfna74

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08354	METTL13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	METTL13	VGNC	VGNC:72093
Felis catus	METTL13	VGNC	VGNC:61733
Rattus norvegicus	METTL13	RGD	RGD:1311526
Bos taurus	METTL13	VGNC	VGNC:31403
Mus musculus	METTL13	MGD	MGI:1918699

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