2. Gene
  3. NLK - nemo like kinase Gene

NLK - nemo like kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 51701 | Gene type: protein coding

About NLK

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,042,677-28,206,074 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in protein stabilization and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NLK Products(1)

mRNA Protein Name
NM_016231.5 NP_057315.3 serine/threonine-protein kinase NLK
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16714285 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
26588989 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16714285 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to osmotic stress IDA
IDA: Inferred from direct assay
26588989 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
26588989 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
25512613 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15004007 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLK Protein Structure

Pkinase

Pkinase: Protein kinase domain (141 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 527 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase NLK

NLK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NLK Q9UBE8 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra NLK Q9UBE8 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra NLK Q9UBE8 QRICH1 Homo sapiens Q2TAL8
Y2H Prey Pooling
25416956
Intra NLK Q9UBE8 QRICH1 Homo sapiens Q2TAL8
Y2H Array
25416956
Intra NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
21988832
Intra NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Confocal
21988832
Intra NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Y2H Array
21988832
Intra NLK Q9UBE8 SMAD4 Homo sapiens Q13485
TAP
23602568
Intra NLK Q9UBE8 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra NLK Q9UBE8 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Array
31515488
Intra NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Array
25416956
Intra NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Prey Pooling
25416956
Intra NLK Q9UBE8 TFDP1 Homo sapiens Q14186
Anti Bait CoIP
22773187
Intra NLK Q9UBE8 DAPK3 Homo sapiens O43293
Anti Bait CoIP
21454679
Intra NLK Q9UBE8 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra NLK Q9UBE8 RCHY1 Homo sapiens Q96PM5
Confocal
21988832
Intra NLK Q9UBE8 RCHY1 Homo sapiens Q96PM5
Y2H Array
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NLK Proteins

Cat. No. Product Name Accession Purity
HY-P76517 NLK/Nemo Like Kinase Protein, Human (sf9, His-GST) Q9UBE8 (V121-E527) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Leber Congenital Amaurosis 1

LCA1

Amaurosis Congenita Of Leber I

Lca

Retinal Blindness, Congenital

Crb

Leber Congenital Amaurosis Type I

Leber Congenital Amaurosis, Type 1

Amaurosis Congenita Of Leber, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS09344 NLK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NLK RGD RGD:1561602
Mus musculus NLK MGD MGI:1201387
Bos taurus NLK VGNC VGNC:32111
Macaca mulatta NLK VGNC VGNC:75277
Felis catus NLK VGNC VGNC:63824
Canis familiaris NLK VGNC VGNC:43841
Others NLK NCBI