NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

Homo sapiens

Also known as NR1; CIAE1; bA350O14.9

Gene ID: 27158 | Gene type: protein coding

About NDOR1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,205,700-137,219,361 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 6.1), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

NDOR1 Products(4)

mRNA	Protein	Name
NM_001144026.3	NP_001137498.1	NADPH-dependent diflavin oxidoreductase 1 isoform a
NM_001144027.3	NP_001137499.1	NADPH-dependent diflavin oxidoreductase 1 isoform d
NM_001144028.3	NP_001137500.1	NADPH-dependent diflavin oxidoreductase 1 isoform c
NM_014434.4	NP_055249.1	NADPH-dependent diflavin oxidoreductase 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables FAD binding	IDA IDA: Inferred from direct assay	10625700	GOA
enables FMN binding	IDA IDA: Inferred from direct assay	10625700	GOA
enables NADP binding	IDA IDA: Inferred from direct assay	15900210	GOA
enables NADPH binding	IDA IDA: Inferred from direct assay	10625700	GOA
enables NADPH-hemoprotein reductase activity	IDA IDA: Inferred from direct assay	10625700	GOA
enables electron transfer activity	IDA IDA: Inferred from direct assay	12631275	GOA
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IDA IDA: Inferred from direct assay	12871938	GOA
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	23596212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16140270	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in electron transport chain	IDA IDA: Inferred from direct assay	10625700	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10625700	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16140270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDOR1 Protein Structure

Flavodoxin_1

FAD_binding_1

NAD_binding_1

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

NADPH-dependent diflavin oxidoreductase 1

NADPH-dependent FMN and FAD-containing oxidoreductase

NDOR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NDOR1	Q9UHB4	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	CENATAC	Homo sapiens	Q86UT8	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	CENATAC	Homo sapiens	Q86UT8	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	LMO3	Homo sapiens	Q8TAP4-4	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	PSMB6	Homo sapiens	P28072	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	PSMB6	Homo sapiens	P28072	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	NLK	Homo sapiens	Q9UBE8	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	NLK	Homo sapiens	Q9UBE8	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	NDOR1	Q9UHB4	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	27519415
Intra	NDOR1	Q9UHB4	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	HOXB2	Homo sapiens	P14652	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	HOXB2	Homo sapiens	P14652	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	NDOR1	Q9UHB4	GPS2	Homo sapiens	Q13227	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	GPS2	Homo sapiens	Q13227	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TCHP	Homo sapiens	Q9BT92	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	TCHP	Homo sapiens	Q9BT92	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	TCHP	Homo sapiens	Q9BT92	Validated Y2H	25416956
Intra	NDOR1	Q9UHB4	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	NDOR1	Q9UHB4	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	NDOR1	Q9UHB4	CIAPIN1	Homo sapiens	Q6FI81	Y2H Prey Pooling	25416956
Intra	NDOR1	Q9UHB4	CIAPIN1	Homo sapiens	Q6FI81	Y2H Array	31515488
Intra	NDOR1	Q9UHB4	CIAPIN1	Homo sapiens	Q6FI81	Validated Y2H	25416956
Intra	NDOR1	Q9UHB4	CIAPIN1	Homo sapiens	Q6FI81	Anti Tag CoIP	27519415
Intra	NDOR1	Q9UHB4	CIAPIN1	Homo sapiens	Q6FI81	Anti Tag CoIP	33961781
Intra	NDOR1	Q9UHB4	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	NDOR1	Q9UHB4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	NDOR1	Q9UHB4	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyschromatosis Universalis Hereditaria

Duh

Atrophic Rhinitis

Rhinitis, Atrophic	Ozena
Rhinitis Sicca	Dry Rhinitis
Ozaena

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09112	NDOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NDOR1	VGNC	VGNC:75050
Bos taurus	NDOR1	VGNC	VGNC:31938
Rattus norvegicus	NDOR1	RGD	RGD:1308479
Mus musculus	NDOR1	MGD	MGI:1926047
Felis catus	NDOR1	VGNC	VGNC:63753
Canis familiaris	NDOR1	VGNC	VGNC:43677

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