TFDP1 - transcription factor Dp-1 Gene

Homo sapiens

Also known as DP1; DILC; Dp-1; DRTF1

Gene ID: 7027 | Gene type: protein coding

About TFDP1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,584,688-113,641,473 (from NCBI)

This gene has 8 transcripts (splice variants), 239 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues.

Summary

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

TFDP1 Products(1)

mRNA	Protein	Name
NM_007111.5	NP_009042.1	transcription factor Dp-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7739537	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16360038	GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7739537	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16360038	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17062573	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	17062573	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7739537	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1531329	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27825926	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	7739537	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	16360038	GOA
part of Rb-E2F complex	IPI IPI: Inferred from physical interaction	16360038	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17062573	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1531329	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFDP1 Protein Structure

E2F_TDP

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

transcription factor Dp-1

DRTF1-polypeptide 1

TFDP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TFDP1	Q14186	NLK	Homo sapiens	Q9UBE8	Anti Bait CoIP	22773187
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	TAP	24981860
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	TAP	27705803
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	Pull Down	16360038
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	TAP	24981860
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	TAP	27705803
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Validated Y2H	32296183
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Y2H Array	32296183
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Y2H Prey Pooling	32296183
Intra	TFDP1	Q14186	E2F2	Homo sapiens	Q14209	TAP	24981860
Intra	TFDP1	Q14186	E2F2	Homo sapiens	Q14209	TAP	27705803
Intra	TFDP1	Q14186	DVL1	Homo sapiens	O14640	Anti Tag CoIP	22773187
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Prey Pooling	32296183
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	TAP	24981860
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	TAP	27705803
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Validated Y2H	25416956
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Array	25416956
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Array	32296183
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Prey Pooling	25416956
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	TAP	24981860
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	TAP	27705803
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	Pull Down	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14417	TFDP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TFDP1	RGD	RGD:1560344
Macaca mulatta	TFDP1	VGNC	VGNC:106302
Mus musculus	TFDP1	MGD	MGI:101934
Felis catus	TFDP1	VGNC	VGNC:102343
Bos taurus	TFDP1	VGNC	VGNC:107256

Name
Email *

	Sorry, but the email address you supplied was invalid.