1. Gene
  2. PF4 - platelet factor 4 Gene

PF4 - platelet factor 4 Gene

Homo sapiens

Also known as PF-4; CXCL4; SCYB4

Gene ID: 5196 | Gene type: protein coding

About PF4

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,980,811-73,982,124 (from NCBI)

This gene has 2 transcripts (splice variants), 22 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 14.3), spleen (RPKM 2.7) and 1 other tissue.

Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous Other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

PF4 Products(2)

mRNA Protein Name
NM_001363352.1 NP_001350281.1 platelet factor 4 isoform 2
NM_002619.4 NP_002610.1 platelet factor 4 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CXCR3 chemokine receptor binding IDA
IDA: Inferred from direct assay
12782716 GOA
enables chemokine activity IDA
IDA: Inferred from direct assay
29930254 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
9531587 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19805618 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
9395524 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12782716 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
10877842 GOA
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
12041672 GOA
involved in defense response to protozoan IDA
IDA: Inferred from direct assay
23245326 GOA
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
23245326 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
10877842 GOA
involved in leukocyte chemotaxis IDA
IDA: Inferred from direct assay
6945600 GOA
involved in monocyte chemotaxis IDA
IDA: Inferred from direct assay
29930254 GOA
involved in negative regulation of MHC class II biosynthetic process IDA
IDA: Inferred from direct assay
10666185 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
1688470 GOA
involved in negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
9395524 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
10666185 GOA
involved in negative regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
2140694 GOA
involved in platelet activation IDA
IDA: Inferred from direct assay
11685038 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
10666185 GOA
involved in positive regulation of macrophage derived foam cell differentiation IDA
IDA: Inferred from direct assay
17244792 GOA
involved in positive regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
10666185 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12782716 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
10666185 GOA
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12782716 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23245326 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
7644496 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PF4 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (39 - 98)

  • 0
  • 101 a.a.
Protein Preferred Names Protein Names

platelet factor 4

C-X-C motif chemokine 4

PF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PF4 P02776 P13501-PRO_0000005175 Homo sapiens P13501-PRO_0000005175
SPR
28381538
Intra
PF4 P02776 CCL17 Homo sapiens Q92583
SPR
28381538
Intra
PF4 P02776 CXCL17 Homo sapiens Q6UXB2
Filter Binding
28381538
Intra
PF4 P02776 CXCL14 Homo sapiens O95715
Filter Binding
28381538
Intra
PF4 P02776 CCL5 Homo sapiens P13501
SPR
28381538
Intra
PF4 P02776 CCL5 Homo sapiens P13501
Filter Binding
28381538
Intra
PF4 P02776 CXCL11 Homo sapiens O14625
Filter Binding
28381538
Intra
PF4 P02776 CXCL9 Homo sapiens Q07325
Filter Binding
28381538
Intra
PF4 P02776 CXCL12 Homo sapiens P48061
Filter Binding
28381538
Intra
PF4 P02776 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
PF4 P02776 CXCL8 Homo sapiens P10145
Filter Binding
28381538
Intra
PF4 P02776 CCL13 Homo sapiens Q99616
Filter Binding
28381538
Intra
PF4 P02776 CCL11 Homo sapiens P51671
Filter Binding
28381538
Intra
PF4 P02776 CCL28 Homo sapiens Q9NRJ3
Filter Binding
28381538
Intra
PF4 P02776 CCL25 Homo sapiens O15444
Filter Binding
28381538
Intra
PF4 P02776 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
Intra
PF4 P02776 CXCL10 Homo sapiens P02778
Filter Binding
28381538
Intra
PF4 P02776 CXCL6 Homo sapiens P80162
Filter Binding
28381538
Intra
PF4 P02776 CCL21 Homo sapiens O00585
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PF4 Proteins

Cat. No. Product Name Accession Purity
HY-P7281 PF-4/CXCL4 Protein, Human (HEK293) P02776 (E32-S101) ≥95%
HY-P70618 PF-4/CXCL4 Protein, Human (HEK293, His) P02776 (E32-S101) ≥95%
HY-P76853 PF-4/CXCL4 Protein, Human P02776 (E32-S101) ≥95%
HY-P700046AF Animal-Free PF-4/CXCL4 Protein, Human (His) P02776 (E32-S101) ≥95%
HY-P700703 PF-4/CXCL4 Protein, Human (His-Avi) NP_002610.1 (E32-S101) ≥95%
HY-P700981 PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) NP_002610.1 (E32-S101) ≥95%

Related Diseases

Diseases Alias
Heparin-Induced Thrombocytopenia

Hit

Hat

Heparin-Associated Thrombocytopenia

Heparin-Induced Thrombocytopenia Type 2

Erythromelalgia

Primary Erythromelalgia

Erythermalgia

Primary Erythermalgia

Mitchell Disease

Familial Erythromelalgia

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Thrombosis

Thrombosis Of Blood Vessel

Intermittent Claudication

Charcot'S Syndrome

Amyotrophic Lateral Sclerosis

Thrombophilia

Hypercoagulability State

Cold Urticaria

Cold Contact Urticaria

Primary Idiopathic Cold Urticaria

Urticaria Idiopathic Cold

Urticaria Due To Cold

Cold-Induced Urticaria

Cold Reflex Urticaria

Antithrombin Iii Deficiency

Hereditary Antithrombin Deficiency

Congenital Antithrombin Iii Deficiency

Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency

AT3D

Thrombophilia Due To Antithrombin Iii Deficiency

Thph7

Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency

Thrombophilia 7 Due To Antithrombin Iii Deficiency

At Iii Deficiency

Congenital At-Iii Deficiency

Inherited Antithrombin Deficiency

Antithrombin 3 Deficiency

Antithrombin Deficiency

Antithrombin-Iii Deficiency

At-Iii Deficiency

Thrombophilia Due To Antithrombin-Iii Deficiency

Mitral Valve Stenosis

Mitral Stenosis

Rheumatic Mitral Stenosis

Ms - [Mitral Stenosis]

Mitral Valvular Stricture

Mitral Valve Stricture

Mitral Stricture

Chronic Mitral Stenosis

Mitral Obstruction

Mitral Valve Obstruction

Mitral Stenosis With Incompetence

Mitral Stenosis With Regurgitation

Rheumatic Mitral Insufficiency With Obstruction

Peripheral Vascular Disease

Peripheral Arterial Disease

Arterial Occlusive Disease

Arterial Occlusive Diseases

Pad

Peripheral Vascular Diseases

Peripheral Occlusive Disease

Peripheral Arterial Diseases

Helicobacter Infections

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Polycythemia Vera

PV

Polycythemia Rubra Vera

Prv

Osler-Vaquez Disease

Chronic Erythremia

Polycythaemia Rubra Vera

Primary Polycythemia

Vaquez Disease

Polycythemia Vera, Somatic

Osler-Vaquez Syndrome

Proliferative Polycythaemia

Polycythemia Ruba Vera

Acquired Primary Erythrocytosis

Heilmeyer-Schoner Disease

Vaquez Osler Disease

Primary Polycythaemia

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome

Hughes Syndrome

Familial Antiphospholipid Syndrome

Aps

Lupus Anticoagulant, Familial

Anti-Phospholipid Syndrome

Apls

Classic Apls

Classic Antiphospholipid Syndrome

Acromegaloid Facial Appearance Syndrome

Anticardiolipin Syndrome

Atrial Fibrillation

A-Fib

Fibrillation, Atrial

Af - [Atrial Fibrillation]

Rapid Atrial Fibrillation

A Fib - [Atrial Fibrillation]

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism

Venous Thrombosis

Thrombophilia Due To Factor 2 Defect

Thromboembolism

THPH1

Thromboembolism, Susceptibility To

Venous Thromboembolism, Susceptibility To

Venous Thrombosis, Protection Against

Prothrombin-Related Thrombophilia

Hyperprothrombinemia

Venous Thrombosis, Susceptibility To

Thrombophilia 1 Due To Thrombin Defect

F2-Related Thrombophilia

Factor Ii-Related Thrombophilia

Prothrombin 20210g>A Thrombophilia

Prothrombin G20210a Thrombophilia

Prothrombin Thrombophilia

Purpura

Purpuric Disorder

Platelet Aggregation, Spontaneous
Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia

Thrombasthenia Of Glanzmann And Naegeli

Glanzmann'S Thrombasthenia

Bdplt2

Platelet Glycoprotein Iib-Iiia Deficiency

Deficiency Of Platelet Fibrinogen Receptor

GT1

Gt

Platelet Fibrinogen Receptor Deficiency

Glycoprotein Complex Iib-Iiia Deficiency

Deficiency Of Glycoprotein Complex Iib-Iiia

Glycoprotein Iib/Iiia Defect

Glanzmann Thrombasthenia, Type A

Thrombasthenia

Bleeding Disorder, Platelet-Type, 2

Gp Iib-Iiia Complex Deficiency

Deficiency Of Gp Iib-Iiia Complex

Platelet-Type Bleeding Disorder 2

Thrombocytasthenia

Deficiency Of Gp 2b 3a Complex

Diacyclothrombopathia 2b 3a

Glanzmann Thrombasthenia Type A

Platelet Fibrinogen Receptor, Deficiency Of

Platelet Glycoprotein 2b 3a Deficiency

Glanzmann Disease

Glanzmann-Naegeli Disorder

Hereditary Hemorrhagic Thrombasthenia

Hereditary Thrombasthenia

Bleeding Disorder Platelet-Type 2

Thrombocytosis

Thrombocythaemia

Vertical Talus, Congenital

Congenital Vertical Talus

CVT

Congenital Convex Pes Valgus

Rocker-Bottom Foot Deformity

Vertical Talus

Pes Valgus, Congenital Convex

Congenital Convex Foot

Congenital Rocker-Bottom Foot

Rocker Bottom Foot

Flatfoot

Rocker-Bottom Foot

Charcot-Marie-Tooth Disease, Foot Deformity Of

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Endocarditis
Erythroleukemia
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Uremia

Uremia Of Renal Origin

Arteritic Anterior Ischemic Optic Neuropathy
Blood Coagulation Disease

Blood Coagulation Disorders

Coagulation Protein Disease

Inherited Blood Coagulation Disease

Postpartum Coagulation Defect

Postpartum Coagulation Defect With Delivery

Coagulation Protein Disorders

Puerperal Coagulopathy

Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia

Autoimmune Thrombocytopenia

Immune Thrombocytopenic Purpura

Itp

Auto-Immune Thrombocytopenia

Thrombocytopenia Due To Immune Destruction

Autoimmune Thrombocytopenic Purpura

Idiopathic Thrombocytopenic Purpura

Werlhof Disease

Sagittal Sinus Thrombosis

Thrombosis Of Superior Longitudinal Sinus

Thrombosis Of Superior Sagittal Sinus

Thrombosis Superior Sagittal Sinus

Intracranial Sinus Thrombosis

Sinus Thrombosis, Intracranial

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Hemorrhagic Disease

Hemorrhagic Disorders

Hemorrhagic Diathesis

Hemorrhagic Diseases

Bleeding Tendency

Acquired Coagulation Factor Inhibitor Disorder

Acquired Inhibitor Of Coagulation

Antithrombinaemia

Antithromboplastinogenaemia

Circulating Anticoagulant Disorder

Haemorrhagic Disorder Due To Antithrombinaemia

Haemorrhagic Disorder Due To Excess Administered Heparin

Antithromboplastinaemia

Haemorrhagic Disorder Due To Hyperheparinemia

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Primary Thrombocytopenia
Raynaud Disease

Raynaud'S Disease

Raynaud Phenomenon

Raynaud'S Syndrome

Raynaud'S

Cold Fingers, Hereditary

Raynaud'S Phenomenon

Raynaud'S Disease/Phenomenon

Raynauds Syndrome

Raynauds Phenomenon

Secondary Raynaud'S Phenomenon

Raynaud Syndrome

Posterolateral Myocardial Infarction
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Cavernous Sinus Thrombosis

Thrombosis Of Cavernous Venous Sinus

Myeloproliferative Neoplasm

Myeloproliferative Disorder

Chronic Myeloproliferative Disease

Myeloproliferative Neoplasms

Chronic Myeloproliferative Disorder

Cmpd

Cmpd, U

Chronic Myeloproliferative Disorders

Mpd

Mpn

Myeloproliferative Disorders

Myeloproliferative Disease

Campomelic Dysplasia

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Intracranial Thrombosis

Cerebral Thrombosis

Thrombosis Of Cerebral Veins

Cerebral Arterial Thrombosis

Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy

Portal Vein Thrombosis

Phlebitis Of Portal Vein

Deep Vein Thrombosis Of Portal Vein

Portal Thrombosis

Pvt - [Portal Vein Thrombosis]

Portal Venous Thrombosis

Portal Venous Embolism

Portal Venous Obstruction

Portal Venous Block

Portal Vein Embolism

Portal Vein Block

Portal Obstruction

Portal Embolism

Portal Block

Hepatic Portal Vein Obstruction

Occlusion Of Hepatic Portal Vein

Portal Vein Obstruction

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura

Autoimmune Thrombocytopenic Purpura

Immune Thrombocytopenic Purpura

Itp

Idiopathic Purpura

AITP

Ideopath Thrombocytopenic Pur

Primary Thrombocytopenic Purpura

Werlhof'S Disease

Thrombocytopenic Purpura Autoimmune

Purpura Thrombocytopenic Idiopathic

Purpura, Thrombocytopenic, Idiopathic

Autoimmune Thrombocytopenia

Thrombocytopenia Due To Platelet Alloimmunization

Idiopathic Thrombocytopenia

Idiopathic Thrombocytopenia Purpura

Frank'S Essential Thrombocytopenia

Itp - [Idiopathic Thrombocytopenia Purpura]

Werlhof Disease

Primary Autoimmune Thrombocytopenic Purpura

Haemorrhagic Purpura

Essential Thrombocytopenia

Purpura Haemorrhagica

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Autoimmune Disease Of Cardiovascular System
Vein Disease

Disorder Of Vein

Diabetes Mellitus

Diabetes

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PF4 RGD RGD:3305
Mus musculus PF4 MGD MGI:1888711
Macaca mulatta PF4 VGNC VGNC:107189
Others PF4 NCBI