2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. Eotaxin/CCL11

Eotaxin/CCL11

Related Products

XLSX 3.92 KB

CCL11, also known as eosinophil chemotactic protein, eotaxin-1, is a small cytokine of the CC chemokine family and in humans is a protein encoded by the CCL11 gene on chromosome 17. CCL11 is constitutively expressed in a variety of tissues including the intestine, lymph nodes, thymus, skin, heart, kidney and breast. CCL11 can act by binding to chemokine receptors including CCR2, CCR3 and CCR5. The primary receptor mediating the biological effects of CCL11 is CCR3, a seven-transmembrane receptor coupled to a heterotrimeric G protein. Eotaxin-1/CCL11 is initially associated with selective recruitment of eosinophils to sites of inflammation during allergic reactions. Once bound to CCR3 receptors expressed on the surface of eosinophils, eotaxin-1/CCL11 activates a series of intracellular signaling cascades that lead to eosinophil recruitment to sites of inflammation. Eosinophils are a source of cytotoxic granule proteins and growth factors responsible for tissue damage and remodeling, respectively, associated with the pathophysiology of a variety of diseases such as asthma. Examples include mycobacterial and schistosome-induced granulomas, which are involved in ischemia-induced remodeling of the vascular wall. It has also been shown that CCL11 is associated with aging, neurogenesis and neurodegeneration and is able to affect neural progenitor cells and microglia as a diagnostic marker[1][2].

Subscribe Now to the List of Recombinant Proteins

Cat. No. Product Name / Synonyms Species Source
  • HY-P7160
    Eotaxin/CCL11 Protein, Mouse

    rMuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11

    		Mouse E. coli
    Eotaxin/CCL11 Protein, Mouse is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.
  • HY-P7159
    Eotaxin/CCL11 Protein, Human

    rHuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11

    		Human E. coli
    Eotaxin/CCL11 Protein, Human is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.
  • HY-P700285
    CCL11 Protein, Rhesus macaque (N-His)

    CCL11; SCYA11Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11

    		Rhesus Macaque E. coli
    The CCL11 protein directly promotes eosinophil accumulation in response to allergens, a key feature of allergic inflammation, without significantly affecting lymphocytes, macrophages, or neutrophils. This selective recruitment highlights the specificity of CCL11 in the coordination of immune responses, particularly in allergy. CCL11 Protein, Rhesus macaque (N-His) is the recombinant Rhesus Macaque-derived CCL11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CCL11 Protein, Rhesus macaque (N-His) is 74 a.a., with molecular weight of ~11 kDa.
  • HY-P71901
    CCL11 Protein, Rat

    Ccl11; Scya11Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

    		Rat E. coli
    CCL11 protein directly promotes eosinophil accumulation in allergic reactions, selectively affecting eosinophils without influencing other immune cells. It binds to CCR3, emphasizing its role in eosinophil-mediated processes. The interaction between CCL11 and its receptor provides insights into the regulation of allergic reactions. CCL11 Protein, Rat is the recombinant rat-derived CCL11 protein, expressed by E. coli , with tag free. The total length of CCL11 Protein, Rat is 74 a.a., with molecular weight of ~10 kDa.
  • HY-P700963
    Eotaxin/CCL11 Protein, Human (His)

    Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1

    		Human E. coli
    Eotaxin/CCL11 Protein actively promotes eosinophil accumulation in response to allergens, a distinctive feature of allergic inflammation, emphasizing its pivotal role in immune response orchestration during allergies. This regulatory function is achieved through binding to the CCR3 receptor, underscoring its specific interaction with cellular receptors to modulate eosinophil migration and activation in response to allergenic stimuli. Eotaxin/CCL11 Protein, Human (His) is the recombinant human-derived Eotaxin/CCL11 protein, expressed by E. coli , with N-His labeled tag. The total length of Eotaxin/CCL11 Protein, Human (His) is 74 a.a., with molecular weight of 13-15 kDa.
Cat. No. Product Name Effect Purity