PFKFB2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

Homo sapiens

Also known as PFK-2/FBPase-2

Gene ID: 5208 | Gene type: protein coding

About PFKFB2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,034,416-207,081,027 (from NCBI)

This gene has 10 transcripts (splice variants), 286 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 25.6), duodenum (RPKM 11.7) and 19 other tissues.

Summary

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related Enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This Enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PFKFB2 Products(2)

mRNA	Protein	Name
NM_001018053.2	NP_001018063.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b
NM_006212.2	NP_006203.2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 6-phosphofructo-2-kinase activity	IDA IDA: Inferred from direct assay	11069105	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8387495	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11069105	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycolytic process	IDA IDA: Inferred from direct assay	11069105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFKFB2 Protein Structure

6PF2K

His_Phos_1

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

6PF-2-K/Fru-2,6-P2ASE heart-type isozyme

PFKFB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PFKFB2	O60825	YWHAZ	Homo sapiens	P63104	Pull Down	15161933

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Lipoma

Lipoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101972	AZ-PFKFB3-67	Inhibitor	97.20%	Unkown
HY-101971	AZ PFKFB3 26	Inhibitor	99.23%	Unkown
HY-101972A	AZ-PFKFB3-67 quarterhydrate	Inhibitor	≥99.0%	Unkown
HY-RS10362	PFKFB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PFKFB2	VGNC	VGNC:32770
Felis catus	PFKFB2	VGNC	VGNC:68804
Rattus norvegicus	PFKFB2	RGD	RGD:3309
Macaca mulatta	PFKFB2	VGNC	VGNC:75958
Mus musculus	PFKFB2	MGD	MGI:107815
Canis familiaris	PFKFB2	VGNC	VGNC:44443
Others	PFKFB2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.