2. Gene
  3. UVRAG - UV radiation resistance associated Gene

UVRAG - UV radiation resistance associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p63; DHTX; VPS38

Gene ID: 7405 | Gene type: protein coding

About UVRAG

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,815,210-76,144,232 (from NCBI)

This gene has 9 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues.

Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting Autophagy and suppressing the proliferation and tumorigenicity of human colon Cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon Cancer. [provided by RefSeq, Jul 2008]

UVRAG Products(5)

mRNA Protein Name
NM_001386671.1 NP_001373600.1 UV radiation resistance-associated gene protein isoform 1
NM_001386672.1 NP_001373601.1 UV radiation resistance-associated gene protein isoform 3
NM_001386673.1 NP_001373602.1 UV radiation resistance-associated gene protein isoform 4
NM_001386674.1 NP_001373603.1 UV radiation resistance-associated gene protein isoform 5
NM_003369.4 NP_003360.2 UV radiation resistance-associated gene protein isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17891140 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
22542840 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
28306502 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
24056303 GOA
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
22542840 GOA
involved in double-strand break repair via classical nonhomologous end joining IDA
IDA: Inferred from direct assay
22542840 GOA
involved in maintenance of Golgi location IMP
IMP: Inferred from mutant phenotype
24056303 GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
8999962 GOA
involved in receptor catabolic process IMP
IMP: Inferred from mutant phenotype
20643123 GOA
involved in regulation of autophagy IDA
IDA: Inferred from direct assay
16799551 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
20643123 GOA
involved in regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22542840 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
24056303 GOA
Cellular Component GO Annotation Evidence Reference Source
part of DNA-dependent protein kinase complex IDA
IDA: Inferred from direct assay
22542840 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
28306502 GOA
located in centrosome IDA
IDA: Inferred from direct assay
22542840 GOA
located in early endosome IDA
IDA: Inferred from direct assay
19270696 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24056303 GOA
located in late endosome IDA
IDA: Inferred from direct assay
19270696 GOA
located in lysosome IDA
IDA: Inferred from direct assay
19270696 GOA
located in midbody IDA
IDA: Inferred from direct assay
20643123 GOA
part of phosphatidylinositol 3-kinase complex, class III IPI
IPI: Inferred from physical interaction
25490155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UVRAG Protein Structure

C2

C2: C2 domain (46 - 95)

Atg14

Atg14: Vacuolar sorting 38 and autophagy-related subunit 14 (185 - 449)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

UV radiation resistance-associated gene protein

beclin 1 binding protein

UVRAG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
22493499
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24056303
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
20562859
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
34386498
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
24056303
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
22493499
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24785657
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Pull Down
25490155
Intra UVRAG Q9P2Y5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24849286
Intra UVRAG Q9P2Y5 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
20562859
Cross UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Bait CoIP
34386498
Cross UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Confocal
34386498
Cross UVRAG Q9P2Y5 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Tag CoIP
34386498
Intra UVRAG Q9P2Y5 SH3GLB1 Homo sapiens Q9Y371
Anti Tag CoIP
24056303
Intra UVRAG Q9P2Y5 SH3GLB1 Homo sapiens Q9Y371
Anti Bait CoIP
24056303
Intra UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
35271311
Intra UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
34386498
Intra UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Pull Down
21062745
Intra UVRAG Q9P2Y5 RUBCN Homo sapiens Q92622
Anti Tag CoIP
20562859
Intra UVRAG Q9P2Y5 BAX Homo sapiens Q07812
Anti Bait CoIP
21597469
Intra UVRAG Q9P2Y5 BAX Homo sapiens Q07812
Anti Tag CoIP
21597469
Intra UVRAG Q9P2Y5 RINT1 Homo sapiens Q6NUQ1
Anti Tag CoIP
24056303
Intra UVRAG Q9P2Y5 RINT1 Homo sapiens Q6NUQ1
Anti Bait CoIP
24056303
Cross UVRAG Q9P2Y5 Slamf1 Mus musculus Q9QUM4
Anti Bait CoIP
22493499
Cross UVRAG Q9P2Y5 Slamf1 Mus musculus Q9QUM4
Anti Tag CoIP
22493499
Intra UVRAG Q9P2Y5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cholecystolithiasis
Cornea Cancer

Malignant Neoplasm Of Cornea

Neoplasm Of Cornea

Corneal Tumor

Malignant Corneal Tumor

Malignant Tumor Of Cornea

Primary Malignant Neoplasm Of Cornea
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor 99.88% Unkown
HY-152100 CUR5g Inhibitor 98.69% Unkown
HY-RS15588 UVRAG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UVRAG VGNC VGNC:78751
Felis catus UVRAG VGNC VGNC:66909
Rattus norvegicus UVRAG RGD RGD:1589754
Mus musculus UVRAG MGD MGI:1925860
Bos taurus UVRAG VGNC VGNC:36751
Canis familiaris UVRAG VGNC VGNC:48218