PIN4 - peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Gene

Homo sapiens

Also known as EPVH; PAR14; PAR17

Gene ID: 5303 | Gene type: protein coding

About PIN4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,181,676-72,263,964 (from NCBI)

This gene has 9 transcripts (splice variants), 231 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 5.5), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

PIN4 Products(2)

mRNA	Protein	Name
NM_001170747.1	NP_001164218.1	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2
NM_006223.4	NP_006214.3	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bent DNA binding	IDA IDA: Inferred from direct assay	12144781	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	17875217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	19369196	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12144781	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17875217	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19369196	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12144781	GOA
part of preribosome	IDA IDA: Inferred from direct assay	19369196	GOA
located in spindle	IDA IDA: Inferred from direct assay	19369196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIN4 Protein Structure

Rotamase_3

0
100
156 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

PPIase PIN4

Recombinant PIN4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71205	PIN4 Protein, Human (His)	Q9Y237-2 (M1-K156)	≥95%

Related Diseases

Diseases

Alias

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10558	PIN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PIN4	VGNC	VGNC:103741
Bos taurus	PIN4	VGNC	VGNC:32903
Rattus norvegicus	PIN4	RGD	RGD:1590326
Mus musculus	PIN4	MGD	MGI:1916963
Others	PIN4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.