2. Gene
  3. SPA17 - sperm autoantigenic protein 17 Gene

SPA17 - sperm autoantigenic protein 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CT22; SP17; SP17-1

Gene ID: 53340 | Gene type: protein coding

About SPA17

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,673,904-124,697,518 (from NCBI)

This gene has 4 transcripts (splice variants), 148 orthologues and 2 paralogues. Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues.

Summary

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

SPA17 Products(1)

mRNA Protein Name
NM_017425.4 NP_059121.1 sperm surface protein Sp17
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15257753 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cilium IDA
IDA: Inferred from direct assay
18421703 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18421703 GOA
located in motile cilium IDA
IDA: Inferred from direct assay
18421703 GOA
located in sperm fibrous sheath IDA
IDA: Inferred from direct assay
19604394 GOA
located in sperm principal piece IDA
IDA: Inferred from direct assay
15257753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPA17 Protein Structure

RIIa

RIIa: Regulatory subunit of type II PKA R-subunit (14 - 51)

IQ

IQ: IQ calmodulin-binding motif (117 - 133)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

sperm surface protein Sp17

cancer/testis antigen 22

SPA17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPA17 Q15506 AKAP7 Homo sapiens O43687-2
Y2H Prey Pooling
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Array
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
MAPPIT
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H
17551920
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Anti Tag CoIP
28514442
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Prey Pooling
25416956
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Array
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Array
25416956
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Anti Tag CoIP
33961781
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Validated Y2H
25416956
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Validated Y2H
32296183
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPA17 Proteins

Cat. No. Product Name Accession Purity
HY-P701069 SP-17 Protein, Human (His) Q15506 (M1-K151) ≥95%

Related Diseases

Diseases Alias
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13613 SPA17 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPA17 RGD RGD:620154
Canis familiaris SPA17 VGNC VGNC:46691
Felis catus SPA17 VGNC VGNC:81934
Macaca mulatta SPA17 VGNC VGNC:77848
Bos taurus SPA17 VGNC VGNC:35160
Mus musculus SPA17 MGD MGI:1333778
Others SPA17 NCBI