ROPN1L - rhophilin associated tail protein 1 like Gene

Homo sapiens

Also known as ASP; RSPH11

Gene ID: 83853 | Gene type: protein coding

About ROPN1L

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:10,441,879-10,482,807 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 83.7).

Summary

This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

ROPN1L Products(2)

mRNA	Protein	Name
NM_001201466.2	NP_001188395.1	ropporin-1-like protein
NM_031916.5	NP_114122.2	ropporin-1-like protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18421703	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	27120127	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18421703	GOA
located in motile cilium	IDA IDA: Inferred from direct assay	18421703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ropporin-1-like protein

AKAP-associated sperm protein

ROPN1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ROPN1L	Q96C74	SPA17	Homo sapiens	Q15506	Anti Tag CoIP	28514442
Intra	ROPN1L	Q96C74	SPA17	Homo sapiens	Q15506	Anti Tag CoIP	33961781
Intra	ROPN1L	Q96C74	RSPH3	Homo sapiens	Q86UC2	Y2H Array	31515488
Intra	ROPN1L	Q96C74	RSPH3	Homo sapiens	Q86UC2	Y2H Array	32296183
Intra	ROPN1L	Q96C74	RSPH3	Homo sapiens	Q86UC2	Y2H Prey Pooling	32296183
Intra	ROPN1L	Q96C74	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	ROPN1L	Q96C74	ROPN1L	Homo sapiens	Q96C74	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Opisthorchiasis

Infection By Opisthorchis	Infection Due To Opisthorchis
Infection Due To Cat Liver Fluke	Infection By Cat Liver Fluke
Opisthorchiosis	Cat Liver Fluke Fever
Cat Liver Fluke Disease	Opisthorchis Infestation
Cat Liver Fluke Infestation

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12123	ROPN1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ROPN1L	VGNC	VGNC:34086
Rattus norvegicus	ROPN1L	RGD	RGD:1591367
Mus musculus	ROPN1L	MGD	MGI:2182357
Canis familiaris	ROPN1L	VGNC	VGNC:45692
Macaca mulatta	ROPN1L	VGNC	VGNC:110437
Felis catus	ROPN1L	VGNC	VGNC:64718

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