2. Gene
  3. PLXNB1 - plexin B1 Gene

PLXNB1 - plexin B1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SEP; PLXN5; PLEXIN-B1

Gene ID: 5364 | Gene type: protein coding

About PLXNB1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,403,854-48,430,310 (from NCBI)

This gene has 19 transcripts (splice variants), 276 orthologues and 8 paralogues. Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues.

Summary

Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

PLXNB1 Products(2)

mRNA Protein Name
NM_001130082.3 NP_001123554.1 plexin-B1 precursor
NM_002673.6 NP_002664.2 plexin-B1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12730235 GOA
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
19843518 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
15218527 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
19843518 GOA
involved in regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
19843518 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
15218527 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19843518 GOA
part of semaphorin receptor complex IDA
IDA: Inferred from direct assay
19843518 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB1 Protein Structure

Sema

Sema: Sema domain (36 - 440)

PSI

PSI: Plexin repeat (481 - 528)

TIG

TIG: IPT/TIG domain (1070 - 1158)

TIG

TIG: IPT/TIG domain (1162 - 1248)

TIG

TIG: IPT/TIG domain (1252 - 1374)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1561 - 2102)

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  • 2135 a.a.
Protein Preferred Names Protein Names

plexin-B1

plexin 5

Recombinant PLXNB1 Proteins

Cat. No. Product Name Accession Purity
HY-P700428 Plexin B1 Protein, Human (HEK293, mFc) O43157 (L20-Q535) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10752 PLXNB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLXNB1 VGNC VGNC:76187
Felis catus PLXNB1 VGNC VGNC:68918
Bos taurus PLXNB1 VGNC VGNC:33061
Canis familiaris PLXNB1 VGNC VGNC:44722
Mus musculus PLXNB1 MGD MGI:2154238
Rattus norvegicus PLXNB1 RGD RGD:1310564
Others PLXNB1 NCBI