PLXNB1 - plexin B1 Gene

Homo sapiens

Also known as SEP; PLXN5; PLEXIN-B1

Gene ID: 5364 | Gene type: protein coding

About PLXNB1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,403,854-48,430,310 (from NCBI)

This gene has 19 transcripts (splice variants), 276 orthologues and 8 paralogues. Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues.

Summary

Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

PLXNB1 Products(2)

mRNA	Protein	Name
NM_001130082.3	NP_001123554.1	plexin-B1 precursor
NM_002673.6	NP_002664.2	plexin-B1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12730235	GOA
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	19843518	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	15218527	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	19843518	GOA
involved in regulation of cytoskeleton organization	IDA IDA: Inferred from direct assay	19843518	GOA
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	15218527	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19843518	GOA
part of semaphorin receptor complex	IDA IDA: Inferred from direct assay	19843518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB1 Protein Structure

Sema

PSI

TIG

Plexin_cytopl

0
400
800
1200
1600
2000
2135 a.a.

Protein Preferred Names

Protein Names

plexin-B1

plexin 5

PLXNB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLXNB1	O43157	MET	Homo sapiens	P08581	Anti Tag CoIP	12198496
Intra	PLXNB1	O43157	MET	Homo sapiens	P08581	Anti Bait CoIP	15184888
Intra	PLXNB1	O43157	MET	Homo sapiens	P08581	Anti Tag CoIP	22404908
Intra	PLXNB1	O43157	RND3	Homo sapiens	P61587	Affinity Techniques	14732713
Intra	PLXNB1	O43157	MST1R	Homo sapiens	Q04912	Anti Bait CoIP	15184888
Intra	PLXNB1	O43157	RND1	Homo sapiens	Q92730	CoIP	12730235

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLXNB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700428	Plexin B1 Protein, Human (HEK293, mFc)	O43157 (L20-Q535)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10752	PLXNB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLXNB1	VGNC	VGNC:76187
Felis catus	PLXNB1	VGNC	VGNC:68918
Bos taurus	PLXNB1	VGNC	VGNC:33061
Canis familiaris	PLXNB1	VGNC	VGNC:44722
Mus musculus	PLXNB1	MGD	MGI:2154238
Rattus norvegicus	PLXNB1	RGD	RGD:1310564
Others	PLXNB1	NCBI

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