RND3 - Rho family GTPase 3 Gene

Homo sapiens

Also known as ARHE; Rho8; RhoE; memB

Gene ID: 390 | Gene type: protein coding

About RND3

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:150,468,193-150,487,695 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues and 22 paralogues. Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues.

Summary

This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

RND3 Products(2)

mRNA	Protein	Name
NM_001254738.1	NP_001241667.1	rho-related GTP-binding protein RhoE precursor
NM_005168.5	NP_005159.1	rho-related GTP-binding protein RhoE precursor

RND3 Protein Structure

Ras

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoE

protein MemB

RND3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RND3	P61587	PLXNB1	Homo sapiens	O43157	ITC	29040270
Intra	RND3	P61587	PLXNB1	Homo sapiens	O43157	GMS	29040270
Intra	RND3	P61587	YWHAZ	Homo sapiens	P63104	ITC	23622247
Intra	RND3	P61587	YWHAZ	Homo sapiens	P63104	Pull Down	23622247
Intra	RND3	P61587	YWHAZ	Homo sapiens	P63104	SPR	23622247
Intra	RND3	P61587	YWHAB	Homo sapiens	P31946	Pull Down	23622247
Intra	RND3	P61587	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	33961781
Intra	RND3	P61587	PLXNB2	Homo sapiens	O15031	ITC	29040270
Intra	RND3	P61587	PLXNB2	Homo sapiens	O15031	GMS	29040270
Intra	RND3	P61587	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	RND3	P61587	CPLANE2	Homo sapiens	Q9BU20	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12033	RND3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RND3	VGNC	VGNC:45618
Rattus norvegicus	RND3	RGD	RGD:1359690
Mus musculus	RND3	MGD	MGI:1921444
Macaca mulatta	RND3	VGNC	VGNC:76883
Felis catus	RND3	VGNC	VGNC:68099
Bos taurus	RND3	VGNC	VGNC:34006

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