FAM3B - FAM3 metabolism regulating signaling molecule B Gene

Homo sapiens

Also known as 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76

Gene ID: 54097 | Gene type: protein coding

About FAM3B

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,304,242-41,357,727 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in duodenum (RPKM 47.4), small intestine (RPKM 44.3) and 11 other tissues.

Summary

Involved in Insulin secretion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

FAM3B Products(2)

mRNA	Protein	Name
NM_058186.4	NP_478066.3	protein FAM3B isoform a precursor
NM_206964.2	NP_996847.1	protein FAM3B isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in insulin secretion	IDA IDA: Inferred from direct assay	12160727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein FAM3B

D21M16SJHU19e

FAM3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAM3B	P58499	FUT3	Homo sapiens	P21217	Y2H Prey Pooling	32296183
Intra	FAM3B	P58499	FUT3	Homo sapiens	P21217	Y2H Array	32296183
Intra	FAM3B	P58499	FUT3	Homo sapiens	P21217	Anti Tag CoIP	33961781
Intra	FAM3B	P58499	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	FAM3B	P58499	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	FAM3B	P58499	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	FAM3B	P58499	LMNA	Homo sapiens	P02545	Y2H Array	32814053
Intra	FAM3B	P58499	LMNA	Homo sapiens	P02545	Validated Y2H	32814053
Intra	FAM3B	P58499	LMNA	Homo sapiens	P02545	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAM3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70386	FAM3B Protein, Human (HEK293, Fc)	P58499-1 (E30-S235)	≥95%
HY-P700631	FAM3B Protein, Human (His)	P58499-1 (E30-S235)	≥95%

Related Diseases

Diseases

Alias

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf	Circumferential Skin Creases, Kunze Type
Congenital Circumferential Skin Folds	Kunze-Riehm Syndrome
Kunze Riehm Syndrome	Michelin Tire Baby Syndrome

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04712	FAM3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FAM3B	MGD	MGI:1270150
Canis familiaris	FAM3B	VGNC	VGNC:40678
Macaca mulatta	FAM3B	VGNC	VGNC:72263
Bos taurus	FAM3B	VGNC	VGNC:28810
Felis catus	FAM3B	VGNC	VGNC:62111
Rattus norvegicus	FAM3B	RGD	RGD:1311662
Others	FAM3B	NCBI

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