RIPK4 - receptor interacting serine/threonine kinase 4 Gene

Homo sapiens

Also known as DIK; PKK; PPS2; RIP4; ANKK2; NKRD3; ANKRD3; CHANDS

Gene ID: 54101 | Gene type: protein coding

About RIPK4

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,739,373-41,767,052 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 5 phenotypes. Broad expression in esophagus (RPKM 16.7), kidney (RPKM 9.9) and 16 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

RIPK4 Products(1)

mRNA	Protein	Name
NM_020639.3	NP_065690.2	receptor-interacting serine/threonine-protein kinase 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21931591	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	22197488	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21931591	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK4 Protein Structure

Pkinase

Ank_2

Ank_4

Ank_2

0
200
400
600
832 a.a.

Protein Preferred Names

Protein Names

receptor-interacting serine/threonine-protein kinase 4

PKC-delta-interacting protein kinase

RIPK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RIPK4	P57078	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	26972000

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bartsocas-Papas Syndrome 1

Bartsocas-Papas Syndrome	Multiple Pterygium Syndrome, Aslan Type
Popliteal Pterygium Syndrome, Lethal Type	Popliteal Pterygium Syndrome, Bartsocas-Papas Type
BPS	Popliteal Pterygium Syndrome Lethal Type
BPS1	Popliteal Pterygium Syndrome, Bartsocas-Papas Type 1
Pterygium, Popliteal, Lethal Type	Bartsocas Papas Syndrome
Pterygium Popliteal Lethal Type	Autosomal Recessive Popliteal Pterygium Syndrome
Lethal Popliteal Pterygium Syndrome

Chand Syndrome

CHANDS	Curly Hair-Ankyloblepharon-Nail Dysplasia Syndrome
Curly Hair, Ankyloblepharon, Nail Dysplasia Syndrome	Baughman Syndrome

Popliteal Pterygium Syndrome

PPS	Faciogenitopopliteal Syndrome
Facio-Genito-Popliteal Syndrome	Popliteal Web Syndrome
Autosomal Dominant Popliteal Pterygium Syndrome	Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies
Popliteal Pterygium Syndrome 1	Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies
Popliteal Pterygium

Fetal Encasement Syndrome

Cocoon Syndrome	COCOS
Fetal Diseases

Synostosis

Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate

Hay-Wells Syndrome	Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome
Aec Syndrome	AEC
Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome	Seres-Santamaria Arimany Muniz Syndrome
Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects	Ankyloblepharon Ectodermal Defects Cleft Lip/Palate
Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate	Rapp-Hodgkin Syndrome

Chronic Cervicitis

Van Der Woude Syndrome

Lip-Pit Syndrome	Vws
Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip	Vdws
Lps	Lip Pit Syndrome
Cleft Lip/Palate With Mucous Cysts Of Lower Lip	Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Multiple Pterygium Syndrome, Escobar Variant

Multiple Pterygium Syndrome	Pterygium
Escobar Syndrome	EVMPS
Pterygium Syndrome	Autosomal Recessive Multiple Pterygium Syndrome
Pterygium Colli Syndrome	Pterygium Universale
Autosomal Recessive Non-Lethal Multiple Pterygium Syndrome	Escobar Variant Multiple Pterygium Syndrome
Multiple Pterygium Syndrome, Nonlethal Type	Surfer'S Eye
Multiple Pterygium Syndrome Escobar Type	Multiple Pterygium Syndrome Nonlethal Type
Familial Pterygium Syndrome	Pterygium Colli
Multiple Pterygium Syndrome, Non-Lethal Type	Nonlethal Type Multiple Pterygium Syndrome
Pterygium Syndrome, Multiple, Escobar Type	Pterygium Of Eye
Web Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148907	CS640	Inhibitor	99.43%	Unkown
HY-RS12001	RIPK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RIPK4	VGNC	VGNC:76882
Bos taurus	RIPK4	VGNC	VGNC:33983
Rattus norvegicus	RIPK4	RGD	RGD:1311691
Canis familiaris	RIPK4	VGNC	VGNC:45596
Felis catus	RIPK4	VGNC	VGNC:67586
Mus musculus	RIPK4	MGD	MGI:1919638

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