PODXL - podocalyxin like Gene

Homo sapiens

Also known as PC; PDX; PCLP; Gp200; gp135; PCLP-1; PODXL1

Gene ID: 5420 | Gene type: protein coding

About PODXL

Cytogenetic location: 7q32.3 Genomic coordinates (GRCh38): 7:131,500,271-131,556,628 (from NCBI)

This gene has 8 transcripts (splice variants), 160 orthologues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 88.8), lung (RPKM 31.4) and 19 other tissues.

Summary

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

PODXL Products(2)

mRNA	Protein	Name
NM_001018111.3	NP_001018121.1	podocalyxin isoform 1 precursor
NM_005397.4	NP_005388.2	podocalyxin isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22662192	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	18456258	GOA
involved in positive regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	18456258	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18456258	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in filopodium	IDA IDA: Inferred from direct assay	18456258	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	18456258	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18456258	GOA
located in ruffle	IDA IDA: Inferred from direct assay	18456258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PODXL Protein Structure

CD34_antigen

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

podocalyxin

GCTM-2 antigen

Recombinant PODXL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71814	PODXL Protein, Human (P.pastoris, His)	O00592 (Q32-F458)	≥95%

Related Diseases

Diseases

Alias

Atypical Juvenile Parkinsonism

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Parkin Type Of Early-Onset Parkinson Disease

Park-Parkin

Prkn Parkinson Disease

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Periampullary Adenocarcinoma

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Ampulla Of Vater Cancer

Ampulla Of Vater Carcinoma	Ampullary Carcinoma
Malignant Tumour Of Ampulla Of Vater	Carcinoma Of Ampulla Of Vater
Carcinoma Of The Ampulla Of Vater	Ampulloma

Nephrotic Syndrome, Type 10

NPHS10	Nephrotic Syndrome Type 10
Idiopathic Steroid-Sensitive Nephrotic Syndrome	Nephrotic Syndrome 10

Familial Nephrotic Syndrome

Congenital Nephrotic Syndrome	Nephrosis, Congenital
Finnish Congenital Nephrotic Syndrome

Lipoid Nephrosis

Minimal Change Disease	Minimal Change Glomerulonephritis
Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis	Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome
Idiopathic Minimal Change Nephrotic Syndrome	Mcns
Minimal Change Glomerulopathy	Minimal Change Nephrotic Syndrome
Nephrotic Syndrome Minimal Change	Nephrosis, Lipoid
Glomerulonephritis, Minimal Change	Nephrotic Syndrome, Minimal Change

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Crescentic Glomerulonephritis

Idiopathic Crescentic Glomerulonephritis

Acute Proliferative Glomerulonephritis

Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Ampulla Of Vater Adenocarcinoma

Adenocarcinoma Of Ampulla Of Vater

Ampullary Adenocarcinoma

Nonaka Myopathy

Gne Myopathy	Hibm
Distal Myopathy With Rimmed Vacuoles	Hereditary Inclusion Body Myopathy
Ibm2	Inclusion Body Myopathy, Quadriceps-Sparing
Qsm	Dmrv
Distal Myopathy, Nonaka Type	Inclusion Body Myopathy 2
Inclusion Body Myopathy, Autosomal Recessive	NM
Nonaka Distal Myopathy	Myopathy, Distal, With Or Without Rimmed Vacuoles
Inclusion Body Myopathy, Hereditary, Autosomal Recessive	Inclusion Body Myopathy Type 2
Quadriceps-Sparing Myopathy	Quadriceps Sparing Myopathy
Rimmed Vacuole Myopathy	Inclusion Body Myopathy 2, Autosomal Recessive, Formerly
Ibm2, Formerly	Hibm2
Hereditary Inclusion Body Myopathy Type 2	Inclusion Body Myopathy 2, Autosomal Recessive
Myopathy, Distal, With Rimmed Vacuoles	Inclusion Body Myopathy Autosomal Recessive
Myopathy, Inclusion Body, Type 2	Myopathy, Nonaka

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Kidney Hypertrophy

Hypertrophy Of Kidney

Frasier Syndrome

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Alport Syndrome

Hereditary Nephritis	Alport Syndrome, X-Linked
Hemorrhagic Hereditary Nephritis	Congenital Hereditary Hematuria
Hemorrhagic Familial Nephritis	Familial Nephritis
Thin Basement Membrane Disease	Thin Basement Membrane Nephropathy
Hematuria-Nephropathy-Deafness Syndrome	Hematuric Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis	Hereditary Hematuria Syndrome
Hereditary Interstitial Pyelonephritis	Alport Deafness-Nephropathy
Alport Hearing Loss-Nephropathy	Alports Syndrome
Nephritis, Hereditary

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10808	PODXL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10809	PODXL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PODXL	VGNC	VGNC:80660
Mus musculus	PODXL	MGD	MGI:1351317
Canis familiaris	PODXL	VGNC	VGNC:54792
Bos taurus	PODXL	VGNC	VGNC:53665
Rattus norvegicus	PODXL	RGD	RGD:621878
Macaca mulatta	PODXL	VGNC	VGNC:76201
Others	PODXL	NCBI

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