2. Gene
  3. IQGAP1 - IQ motif containing GTPase activating protein 1 Gene

IQGAP1 - IQ motif containing GTPase activating protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAR1; p195; HUMORFA01

Gene ID: 8826 | Gene type: protein coding

About IQGAP1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,388,242-90,502,239 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 49.8), appendix (RPKM 48.4) and 25 other tissues.

Summary

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the Cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric Cancer cell lines. [provided by RefSeq, Jul 2008]

IQGAP1 Products(1)

mRNA Protein Name
NM_003870.4 NP_003861.1 ras GTPase-activating-like protein IQGAP1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MAP-kinase scaffold activity IPI
IPI: Inferred from physical interaction
18567582 GOA
enables S100 protein binding IPI
IPI: Inferred from physical interaction
25554515 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
18567582 GOA
enables calmodulin binding IDA
IDA: Inferred from direct assay
18567582 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
26242911 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
22493426 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10793131 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
25554515 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17563371 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
16380380 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
17563371 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
26242911 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
26242911 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
18567582 GOA
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
17563371 GOA
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17563371 GOA
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
15695813 GOA
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
18567582 GOA
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
17563371 GOA
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20883816 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
35601831 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
25554515 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
22493426 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
located in midbody IDA
IDA: Inferred from direct assay
15166316 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20883816 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
29033352 GOA
located in ruffle IDA
IDA: Inferred from direct assay
25554515 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IQGAP1 Protein Structure

CH

CH: Calponin homology (CH) domain (49 - 158)

IQ

IQ: IQ calmodulin-binding motif (749 - 766)

IQ

IQ: IQ calmodulin-binding motif (778 - 796)

IQ

IQ: IQ calmodulin-binding motif (809 - 826)

IQ

IQ: IQ calmodulin-binding motif (839 - 856)

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (1025 - 1237)

RasGAP_C

RasGAP_C: RasGAP C-terminus (1451 - 1581)

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  • 1500
  • 1657 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating-like protein IQGAP1

RasGAP-like with IQ motifs

IQGAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross IQGAP1 P46940 Diaph1 Mus musculus O08808
Pull Down
17620407
Intra IQGAP1 P46940 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra IQGAP1 P46940 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra IQGAP1 P46940 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra IQGAP1 P46940 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra IQGAP1 P46940 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra IQGAP1 P46940 LBX1 Homo sapiens P52954
Validated Y2H
32296183
Intra IQGAP1 P46940 LBX1 Homo sapiens P52954
Y2H Array
32296183
Intra IQGAP1 P46940 LBX1 Homo sapiens P52954
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra IQGAP1 P46940 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra IQGAP1 P46940 CXCR2 Homo sapiens P25025
Crosslink
21876773
Intra IQGAP1 P46940 EGFR Homo sapiens P00533
Anti Bait CoIP
21349850
Intra IQGAP1 P46940 EGFR Homo sapiens P00533
Confocal
21349850
Intra IQGAP1 P46940 EGFR Homo sapiens P00533
Pull Down
21349850
Intra IQGAP1 P46940 CD2AP Homo sapiens Q9Y5K6
Confocal
22662192
Intra IQGAP1 P46940 CD2AP Homo sapiens Q9Y5K6
PLA
22662192
Intra IQGAP1 P46940 CD2AP Homo sapiens Q9Y5K6
Anti Bait CoIP
22662192
Intra IQGAP1 P46940 TSG101 Homo sapiens Q99816
Anti Tag CoIP
17853893
Intra IQGAP1 P46940 TSG101 Homo sapiens Q99816
Affinity Chrom
17853893
Intra IQGAP1 P46940 TSG101 Homo sapiens Q99816
Y2H
17853893
Intra IQGAP1 P46940 ACTN4 Homo sapiens O43707
Anti Tag CoIP
26496610
Intra IQGAP1 P46940 ACTN4 Homo sapiens O43707
Anti Bait CoIP
22662192
Intra IQGAP1 P46940 ILF2 Homo sapiens Q12905
Validated Y2H
32296183
Intra IQGAP1 P46940 ILF2 Homo sapiens Q12905
Y2H Array
32296183
Intra IQGAP1 P46940 ILF2 Homo sapiens Q12905
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 BRAF Homo sapiens P15056
Pull Down
17563371
Intra IQGAP1 P46940 BRAF Homo sapiens P15056
Anti Tag CoIP
17563371
Intra IQGAP1 P46940 RAC1 Homo sapiens P63000
Anti Bait CoIP
18809683
Intra IQGAP1 P46940 RAC1 Homo sapiens P63000
Anti Bait CoIP
23982733
Intra IQGAP1 P46940 ARF1 Homo sapiens P84077
Anti Bait CoIP
36396045
Intra IQGAP1 P46940 CTNNB1 Homo sapiens P35222
Confocal
22662192
Intra IQGAP1 P46940 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
22662192
Intra IQGAP1 P46940 ERBB2 Homo sapiens P04626
Anti Bait CoIP
21724847
Intra IQGAP1 P46940 ERBB2 Homo sapiens P04626
Pull Down
21724847
Intra IQGAP1 P46940 NPHS2 Homo sapiens Q9NP85
PLA
22662192
Intra IQGAP1 P46940 NPHS2 Homo sapiens Q9NP85
Anti Bait CoIP
22662192
Intra IQGAP1 P46940 PODXL Homo sapiens O00592
PLA
22662192
Intra IQGAP1 P46940 BCAR1 Homo sapiens P56945
Pull Down
28007913
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Anti Bait CoIP
21876773
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Pull Down
12745076
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Crosslink
21876773
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Anti Tag CoIP
26496610
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Imaging
8670801
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Imaging
8798539
Intra IQGAP1 P46940 CDC42 Homo sapiens P60953
Anti Bait CoIP
18809683
Intra IQGAP1 P46940 PIP5K1C Homo sapiens O60331-4
Anti Bait CoIP
23982733
Intra IQGAP1 P46940 PIP5K1C Homo sapiens O60331-4
Anti Tag CoIP
23982733
Intra IQGAP1 P46940 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra IQGAP1 P46940 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra IQGAP1 P46940 MAGI1 Homo sapiens Q96QZ7
Anti Bait CoIP
22662192
Intra IQGAP1 P46940 NPHS1 Homo sapiens O60500
Anti Bait CoIP
22662192
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 3

NPHS3

Nephrotic Syndrome Type 3

Nephrotic Syndrome, Early-Onset, Type 3

Early Onset Nephrotic Syndrome Type 3

Nephrotic Syndrome 3

Early-Onset Nephrotic Syndrome Type 3
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163707 UR778Br Inducer 99.20% Unkown
HY-RS06885 IQGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IQGAP1 VGNC VGNC:73755
Bos taurus IQGAP1 VGNC VGNC:30258
Mus musculus IQGAP1 MGD MGI:1352757
Canis familiaris IQGAP1 VGNC VGNC:42081
Felis catus IQGAP1 VGNC VGNC:67817
Rattus norvegicus IQGAP1 RGD RGD:1311884