2. Gene
  3. POLR2J - RNA polymerase II subunit J Gene

POLR2J - RNA polymerase II subunit J Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB11; RPB11A; RPB11m; hRPB14; POLR2J1

Gene ID: 5439 | Gene type: protein coding

About POLR2J

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,473,128-102,478,922 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 20.7), fat (RPKM 18.2) and 25 other tissues.

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

POLR2J Products(3)

mRNA Protein Name
NM_001371100.1 NP_001358029.1 DNA-directed RNA polymerase II subunit RPB11-a isoform 2
NM_001393919.1 NP_001380848.1 DNA-directed RNA polymerase II subunit RPB11-a isoform 3
NM_006234.6 NP_006225.1 DNA-directed RNA polymerase II subunit RPB11-a isoform 1

POLR2J Protein Structure

RNA_pol_L_2

RNA_pol_L_2: RNA polymerase Rpb3/Rpb11 dimerisation domain (29 - 105)

  • 0
  • 100
  • 117 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB11-a

DNA-directed RNA polymerase II subunit J-1

Related Diseases

Diseases Alias
Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta

IMD25

Immunodeficiency, Type 25
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10851 POLR2J Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10852 POLR2J3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus POLR2J RGD RGD:1310198
Mus musculus POLR2J MGD MGI:109582