2. Gene
  3. POLR1C - RNA polymerase I and III subunit C Gene

POLR1C - RNA polymerase I and III subunit C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AC40; RPA5; TCS3; HLD11; RPA39; RPA40; RPAC1; RPC40

Gene ID: 9533 | Gene type: protein coding

About POLR1C

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,517,089-44,461,400 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues, 2 paralogues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 7.7), skin (RPKM 5.6) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

POLR1C Products(3)

mRNA Protein Name
NM_001318876.2 NP_001305805.1 DNA-directed RNA polymerases I and III subunit RPAC1 isoform 2
NM_001363658.2 NP_001350587.1 DNA-directed RNA polymerases I and III subunit RPAC1 isoform 3
NM_203290.4 NP_976035.1 DNA-directed RNA polymerases I and III subunit RPAC1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
34671025 GOA
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
24107381 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
33335104 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33335104 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR1C Protein Structure

RNA_pol_L

RNA_pol_L: RNA polymerase Rpb3/Rpb11 dimerisation domain (61 - 333)

RNA_pol_A_bac

RNA_pol_A_bac: RNA polymerase Rpb3/RpoA insert domain (92 - 226)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerases I and III subunit RPAC1

DNA-directed RNA polymerase I subunit C

POLR1C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POLR1C O15160 TASOR2 Homo sapiens Q5VWN6-2
Validated Y2H
25416956
Intra
POLR1C O15160 TASOR2 Homo sapiens Q5VWN6-2
Y2H Array
25416956
Intra
POLR1C O15160 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
POLR1C O15160 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
POLR1C O15160 KRTAP12-2 Homo sapiens P59991
Validated Y2H
32296183
Intra
POLR1C O15160 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
POLR1C O15160 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MBIP Homo sapiens Q9NS73-5
Validated Y2H
25416956
Intra
POLR1C O15160 MBIP Homo sapiens Q9NS73-5
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
32296183
Intra
POLR1C O15160 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 RIMBP3 Homo sapiens Q9UFD9
Validated Y2H
25416956
Intra
POLR1C O15160 RIMBP3 Homo sapiens Q9UFD9
Validated Y2H
32296183
Intra
POLR1C O15160 C1orf105 Homo sapiens O95561
Validated Y2H
32296183
Intra
POLR1C O15160 C1orf105 Homo sapiens O95561
Y2H Array
32296183
Intra
POLR1C O15160 C1orf105 Homo sapiens O95561
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 GSTO2 Homo sapiens Q9H4Y5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 GSTO2 Homo sapiens Q9H4Y5
Validated Y2H
32296183
Intra
POLR1C O15160 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
32296183
Intra
POLR1C O15160 C21orf58 Homo sapiens Q0VAL7
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 C21orf58 Homo sapiens Q0VAL7
Validated Y2H
32296183
Intra
POLR1C O15160 C21orf58 Homo sapiens Q0VAL7
Y2H Array
32296183
Intra
POLR1C O15160 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
POLR1C O15160 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra
POLR1C O15160 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLDIP3 Homo sapiens Q8WUT1
Y2H Array
32296183
Intra
POLR1C O15160 POLDIP3 Homo sapiens Q8WUT1
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLDIP3 Homo sapiens Q8WUT1
Validated Y2H
32296183
Intra
POLR1C O15160 GRPEL1 Homo sapiens Q9HAV7
Validated Y2H
32296183
Intra
POLR1C O15160 GRPEL1 Homo sapiens Q9HAV7
MAPPIT
32296183
Intra
POLR1C O15160 GRPEL1 Homo sapiens Q9HAV7
Y2H Array
32296183
Intra
POLR1C O15160 GRPEL1 Homo sapiens Q9HAV7
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 FH Homo sapiens P07954
Y2H Array
32296183
Intra
POLR1C O15160 FH Homo sapiens P07954
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 FH Homo sapiens P07954
Validated Y2H
32296183
Intra
POLR1C O15160 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
POLR1C O15160 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra
POLR1C O15160 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 HDX Homo sapiens Q7Z353
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 HDX Homo sapiens Q7Z353
Validated Y2H
32296183
Intra
POLR1C O15160 HDX Homo sapiens Q7Z353
Y2H Array
32296183
Intra
POLR1C O15160 MRPS23 Homo sapiens Q9Y3D9
Validated Y2H
32296183
Intra
POLR1C O15160 MRPS23 Homo sapiens Q9Y3D9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MRPS23 Homo sapiens Q9Y3D9
Y2H Array
32296183
Intra
POLR1C O15160 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
POLR1C O15160 TFIP11 Homo sapiens Q9UBB9
BFG-2H
27107012
Intra
POLR1C O15160 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
POLR1C O15160 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
POLR1C O15160 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
POLR1C O15160 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 GPRASP3 Homo sapiens Q6PI77
Validated Y2H
32296183
Intra
POLR1C O15160 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
POLR1C O15160 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
POLR1C O15160 CBY2 Homo sapiens Q8NA61-2
BFG-2H
27107012
Intra
POLR1C O15160 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra
POLR1C O15160 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
POLR1C O15160 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
POLR1C O15160 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
POLR1C O15160 ZIM2 Homo sapiens Q9NZV7
Y2H Array
32296183
Intra
POLR1C O15160 ZIM2 Homo sapiens Q9NZV7
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
POLR1C O15160 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
POLR1C O15160 FMR1 Homo sapiens Q8IXW7
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 FMR1 Homo sapiens Q8IXW7
Validated Y2H
32296183
Intra
POLR1C O15160 FMR1 Homo sapiens Q8IXW7
Y2H Array
32296183
Intra
POLR1C O15160 NEDD4 Homo sapiens P46934-3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 NEDD4 Homo sapiens P46934-3
Validated Y2H
32296183
Intra
POLR1C O15160 NEDD4 Homo sapiens P46934-3
Y2H Array
32296183
Intra
POLR1C O15160 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra
POLR1C O15160 SPATC1L Homo sapiens Q9H0A9-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 SPATC1L Homo sapiens Q9H0A9-2
Y2H Array
32296183
Intra
POLR1C O15160 CCNK Homo sapiens O75909-2
Validated Y2H
32296183
Intra
POLR1C O15160 CCNK Homo sapiens O75909-2
Y2H Array
32296183
Intra
POLR1C O15160 CCNK Homo sapiens O75909-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 SPMIP2 Homo sapiens Q96LM5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 SPMIP2 Homo sapiens Q96LM5
Validated Y2H
32296183
Intra
POLR1C O15160 SPMIP2 Homo sapiens Q96LM5
Y2H Array
32296183
Intra
POLR1C O15160 EP400 Homo sapiens A0A0A0MR80
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 EP400 Homo sapiens A0A0A0MR80
Y2H Array
32296183
Intra
POLR1C O15160 TMEM121 Homo sapiens Q9BTD3
Y2H Array
32296183
Intra
POLR1C O15160 TMEM121 Homo sapiens Q9BTD3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TMEM121 Homo sapiens Q9BTD3
Validated Y2H
32296183
Intra
POLR1C O15160 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
POLR1C O15160 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
POLR1C O15160 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
Intra
POLR1C O15160 NDUFB10 Homo sapiens O96000
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 NDUFB10 Homo sapiens O96000
Validated Y2H
32296183
Intra
POLR1C O15160 NDUFB10 Homo sapiens O96000
Y2H Array
32296183
Intra
POLR1C O15160 UNKL Homo sapiens Q9H9P5-5
Validated Y2H
32296183
Intra
POLR1C O15160 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32296183
Intra
POLR1C O15160 UNKL Homo sapiens Q9H9P5-5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLR2J3 Homo sapiens Q9H1A7
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLR2J3 Homo sapiens Q9H1A7
Validated Y2H
32296183
Intra
POLR1C O15160 ZFP57 Homo sapiens Q9NU63-3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZFP57 Homo sapiens Q9NU63-3
Validated Y2H
32296183
Intra
POLR1C O15160 ZFP57 Homo sapiens Q9NU63-3
Y2H Array
32296183
Intra
POLR1C O15160 ZNF547 Homo sapiens Q8IVP9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZNF547 Homo sapiens Q8IVP9
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF547 Homo sapiens Q8IVP9
Y2H Array
32296183
Intra
POLR1C O15160 ZC2HC1C Homo sapiens Q53FD0-2
Validated Y2H
32296183
Intra
POLR1C O15160 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
POLR1C O15160 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
POLR1C O15160 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
POLR1C O15160 HOXD12 Homo sapiens P35452-2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 HOXD12 Homo sapiens P35452-2
Validated Y2H
32296183
Intra
POLR1C O15160 HOXD12 Homo sapiens P35452-2
Y2H Array
32296183
Intra
POLR1C O15160 TRAIP Homo sapiens Q9BWF2
Y2H Array
32296183
Intra
POLR1C O15160 TRAIP Homo sapiens Q9BWF2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TRAIP Homo sapiens Q9BWF2
Validated Y2H
32296183
Intra
POLR1C O15160 SPMIP10 Homo sapiens Q6ZNM6
Validated Y2H
32296183
Intra
POLR1C O15160 SPMIP10 Homo sapiens Q6ZNM6
Y2H Array
32296183
Intra
POLR1C O15160 SPMIP10 Homo sapiens Q6ZNM6
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZNF554 Homo sapiens Q86TJ5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZNF554 Homo sapiens Q86TJ5
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF554 Homo sapiens Q86TJ5
Y2H Array
32296183
Intra
POLR1C O15160 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
POLR1C O15160 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
POLR1C O15160 MKRN3 Homo sapiens Q13064
BFG-2H
27107012
Intra
POLR1C O15160 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra
POLR1C O15160 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
POLR1C O15160 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra
POLR1C O15160 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra
POLR1C O15160 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 TNFAIP1 Homo sapiens Q13829
Validated Y2H
32296183
Intra
POLR1C O15160 TNFAIP1 Homo sapiens Q13829
Y2H Array
25416956
Intra
POLR1C O15160 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
POLR1C O15160 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
POLR1C O15160 PPP2R3C Homo sapiens Q969Q6
Y2H Array
25416956
Intra
POLR1C O15160 PPP2R3C Homo sapiens Q969Q6
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 BIN3 Homo sapiens Q9NQY0
Validated Y2H
32296183
Intra
POLR1C O15160 BIN3 Homo sapiens Q9NQY0
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 BIN3 Homo sapiens Q9NQY0
Y2H Array
32296183
Intra
POLR1C O15160 KLF15 Homo sapiens Q9UIH9
Validated Y2H
32296183
Intra
POLR1C O15160 KLF15 Homo sapiens Q9UIH9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KLF15 Homo sapiens Q9UIH9
Y2H Array
32296183
Intra
POLR1C O15160 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TRIM14 Homo sapiens Q14142
Validated Y2H
32296183
Intra
POLR1C O15160 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
POLR1C O15160 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
POLR1C O15160 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
POLR1C O15160 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 XPA Homo sapiens P23025
Validated Y2H
32296183
Intra
POLR1C O15160 XPA Homo sapiens P23025
Y2H Array
32296183
Intra
POLR1C O15160 XPA Homo sapiens P23025
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KRT76 Homo sapiens Q01546
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KRT76 Homo sapiens Q01546
Validated Y2H
32296183
Intra
POLR1C O15160 KRT76 Homo sapiens Q01546
Y2H Array
32296183
Intra
POLR1C O15160 POLR2G Homo sapiens P62487
Validated Y2H
32296183
Intra
POLR1C O15160 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra
POLR1C O15160 HNRNPH1 Homo sapiens P31943
Validated Y2H
32296183
Intra
POLR1C O15160 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
POLR1C O15160 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 CCT3 Homo sapiens P49368
Validated Y2H
32296183
Intra
POLR1C O15160 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra
POLR1C O15160 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H Pooling
16189514
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
MAPPIT
32296183
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Anti Tag CoIP
35271311
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H
21988832
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Validated Y2H
32296183
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H Array
25416956
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Complementation
32296183
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Anti Tag CoIP
33961781
Intra
POLR1C O15160 POLR1D Homo sapiens P0DPB6
Y2H Array
32296183
Intra
POLR1C O15160 SPRY1 Homo sapiens O43609
Validated Y2H
32296183
Intra
POLR1C O15160 SPRY1 Homo sapiens O43609
Y2H Array
32296183
Intra
POLR1C O15160 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 POLR2J Homo sapiens P52435
Validated Y2H
25416956
Intra
POLR1C O15160 POLR2J Homo sapiens P52435
Validated Y2H
32296183
Intra
POLR1C O15160 POLR2J Homo sapiens P52435
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Validated Y2H
25416956
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Validated Y2H
32296183
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Y2H Array
25416956
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Y2H Array
32296183
Intra
POLR1C O15160 SMN1 Homo sapiens Q16637
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 SAXO1 Homo sapiens Q8IYX7
Y2H Array
25416956
Intra
POLR1C O15160 ZNF688 Homo sapiens P0C7X2
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
POLR1C O15160 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 LRIF1 Homo sapiens Q5T3J3
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 LRIF1 Homo sapiens Q5T3J3
Y2H Array
32296183
Intra
POLR1C O15160 LRIF1 Homo sapiens Q5T3J3
Validated Y2H
32296183
Intra
POLR1C O15160 RBM48 Homo sapiens Q5RL73
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 RBM48 Homo sapiens Q5RL73
Validated Y2H
32296183
Intra
POLR1C O15160 RBM48 Homo sapiens Q5RL73
Y2H Array
32296183
Intra
POLR1C O15160 BIRC7 Homo sapiens Q96CA5
Validated Y2H
32296183
Intra
POLR1C O15160 BIRC7 Homo sapiens Q96CA5
Y2H Array
25416956
Intra
POLR1C O15160 BIRC7 Homo sapiens Q96CA5
Y2H Array
32296183
Intra
POLR1C O15160 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
POLR1C O15160 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
POLR1C O15160 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
POLR1C O15160 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra
POLR1C O15160 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
POLR1C O15160 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF835 Homo sapiens Q9Y2P0
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 ZNF835 Homo sapiens Q9Y2P0
Y2H Array
32296183
Intra
POLR1C O15160 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
POLR1C O15160 ARHGEF5 Homo sapiens Q12774
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
POLR1C O15160 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
POLR1C O15160 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
POLR1C O15160 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
POLR1C O15160 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
POLR1C O15160 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
POLR1C O15160 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
POLR1C O15160 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra
POLR1C O15160 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
POLR1C O15160 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
POLR1C O15160 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
32296183
Intra
POLR1C O15160 CGGBP1 Homo sapiens Q9UFW8
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 CGGBP1 Homo sapiens Q9UFW8
Y2H Array
32296183
Intra
POLR1C O15160 STMN3 Homo sapiens Q9NZ72
Validated Y2H
32296183
Intra
POLR1C O15160 STMN3 Homo sapiens Q9NZ72
Y2H Array
32296183
Intra
POLR1C O15160 STMN3 Homo sapiens Q9NZ72
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra
POLR1C O15160 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
Intra
POLR1C O15160 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
Intra
POLR1C O15160 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra
POLR1C O15160 CRACR2A Homo sapiens Q9BSW2
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 CRACR2A Homo sapiens Q9BSW2
Y2H Array
32296183
Intra
POLR1C O15160 ZBED1 Homo sapiens O96006
Validated Y2H
32296183
Intra
POLR1C O15160 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
POLR1C O15160 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra
POLR1C O15160 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
POLR1C O15160 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Y2H Array
31515488
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Validated Y2H
32296183
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Validated Y2H
25416956
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Y2H Array
25416956
Intra
POLR1C O15160 NME1 Homo sapiens P15531
Y2H Array
32296183
Intra
POLR1C O15160 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
POLR1C O15160 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 SORBS3 Homo sapiens O60504
Validated Y2H
32296183
Intra
POLR1C O15160 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KCTD13 Homo sapiens Q8WZ19
Validated Y2H
32296183
Intra
POLR1C O15160 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Intra
POLR1C O15160 NME4 Homo sapiens O00746
Y2H Array
32296183
Intra
POLR1C O15160 NME4 Homo sapiens O00746
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 HOXB9 Homo sapiens P17482
Validated Y2H
32296183
Intra
POLR1C O15160 HOXB9 Homo sapiens P17482
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 HOXB9 Homo sapiens P17482
Y2H Array
32296183
Intra
POLR1C O15160 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra
POLR1C O15160 TNNI1 Homo sapiens P19237
Validated Y2H
32296183
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
BFG-2H
27107012
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
POLR1C O15160 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
POLR1C O15160 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra
POLR1C O15160 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra
POLR1C O15160 GMPPB Homo sapiens Q9Y5P6
Validated Y2H
32296183
Intra
POLR1C O15160 GMPPB Homo sapiens Q9Y5P6
Y2H Array
32296183
Intra
POLR1C O15160 GMPPB Homo sapiens Q9Y5P6
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 FOXR2 Homo sapiens Q6PJQ5
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 FOXR2 Homo sapiens Q6PJQ5
Validated Y2H
32296183
Intra
POLR1C O15160 FOXR2 Homo sapiens Q6PJQ5
Y2H Array
32296183
Intra
POLR1C O15160 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
POLR1C O15160 IHO1 Homo sapiens Q8IYA8
Y2H Array
25416956
Intra
POLR1C O15160 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
POLR1C O15160 AVPI1 Homo sapiens Q5T686
Validated Y2H
32296183
Intra
POLR1C O15160 AVPI1 Homo sapiens Q5T686
Y2H Array
32296183
Intra
POLR1C O15160 AVPI1 Homo sapiens Q5T686
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KCTD1 Homo sapiens Q719H9
Validated Y2H
25416956
Intra
POLR1C O15160 KCTD1 Homo sapiens Q719H9
Validated Y2H
32296183
Intra
POLR1C O15160 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KCTD1 Homo sapiens Q719H9
Y2H Array
32296183
Intra
POLR1C O15160 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Intra
POLR1C O15160 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Intra
POLR1C O15160 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
POLR1C O15160 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
POLR1C O15160 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Treacher Collins Syndrome 3

TCS3

Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive

Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive
Leukodystrophy, Hypomyelinating, 11

Hypomyelinating Leukodystrophy 11

HLD11

4h Leukodystrophy 3

Leukodystrophy, Hypomyelinating, Type 11
Primary Bone Dysplasia With Multiple Joint Dislocations

Primary Osteodysplasia With Multiple Joint Dislocations

Primary Skeletal Dysplasia With Multiple Joint Dislocations
Fetal Erythroblastosis

Erythroblastosis, Fetal

Ef - Erythroblastosis Foetalis

Erythroblastosis Fetalis

Haemolytic Disease Due To Rhesus Isoimmunisation

Rhesus Isoimmunisation Of The Newborn
Jaberi-Elahi Syndrome

JABELS
Leukoencephalopathy, Progressive, With Ovarian Failure

LKENP
Combined Oxidative Phosphorylation Deficiency 8

COXPD8

Combined Oxidative Phosphorylation Defect Type 8

Cardiomyopathy, Hypertrophic Mitochondrial, Fatal Infantile

Cardiomyopathy Hypertrophic Mitochondrial Fatal Infantile

Combined Oxidative Phosphorylation Deficiency, Type 8
Ciliary Dyskinesia, Primary, 12

CILD12

Primary Ciliary Dyskinesia 12

Primary Ciliary Dyskinesia 12 Without Situs Inversus

Ciliary Dyskinesia, Primary, 12, Without Situs Inversus

Ics12

Immotile Cilia Syndrome 12

Dyskinesia, Ciliary, Primary, Type 12
Carey-Fineman-Ziter Syndrome 2

CFZS2
Polr3-Related Leukodystrophy

Pol Iii-Related Leukodystrophy

4h Syndrome

4h Leukodystrophy

Hypomyelination-Hypogonadotropic Hypogonadism-Hypodontia Syndrome

Pol Iii Disorder

Pol Iii-Related Hypomyelinating Leukodystrophies

Ribonucleic Acid Polymerase Iii-Related Leukodystrophy

Dentoleukoencephalopathy

Leukodystrophy With Oligodontia

Odontoleukodystrophy

Hypomyelinating Leukodystrophy With Or Without Oligondontia And/Or Hypogonadism

Addh

Ataxia, Delayed Dentition, And Hypomyelination

Hcahc

Hld7

Hld8

Hypomyelination With Cerebellar Atrophy And Hypoplasia Of The Corpus Callosum

Hypomyelination, Hypodontia, Hypogonadotropic Hypogonadism

Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

Leukoencephalopathy-Ataxia-Hypodontia-Hypomyelination

Lo

Tach

Tremor-Ataxia With Central Hypomyelination

Polr-Related Leukodystrophy
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Microvascular Complications Of Diabetes 1

Proliferative Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 1

MVCD1

Diabetic Nephropathy

Non-Proliferative Diabetic Retinopathy

Nonproliferative Diabetic Retinopathy

Proliferative Retinopathy, Diabetic

Proliferative Retinopathy, Diabetic, Susceptibility To

Nonproliferative Retinopathy, Diabetic

Nonproliferative Retinopathy, Diabetic, Susceptibility To

Pdr

Diabetic End-Stage Renal Disease

Diabetic Neuropathy

Diabetic Neuropathies

Complications Of Diabetes Mellitus

Diabetes Mellitus, Independent Of Type With Proliferative Retinopathy
Leukodystrophy

Leukodystrophies
Superior Semicircular Canal Dehiscence

Superior Canal Dehiscence Syndrome

Superior Semicircular Canal Dehiscence Syndrome

Canal Dehiscence Syndrome

Superior Canal Dehiscence

Superior Canal Syndrome

Third Mobile Window Syndrome

Scds

Anemia, Sickle Cell
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Amusia

Receptive Amusia
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder
Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis
Acrofacial Dysostosis, Cincinnati Type

Acrofacial Dysostosis Cincinnati Type

AFDCIN

Dysostosis, Acrofacial, Cincinnati Type
Labyrinthitis

Labyrinthine Disorder

Inner Ear Inflammation

Otitis Interna

Labyrinth Hyperaemia
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3

EEC3

Eec Syndrome 3

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Peripheral Vertigo

Vertigo, Peripheral
Mouth Disease

Mouth Diseases

Mouth Disorders
Meniere Disease

Meniere'S Disease

Otogenic Vertigo

Ménière Disease

Ménière'S Disease

Mnire'S Vertigo

Auditory Vertigo

Aural Vertigo

Meniere'S Syndrome

Ménière'S Vertigo

Primary Endolymphatic Hydrops

Menieres Disease

Vertigo, Aural

Labyrinth Hydrops

Labyrinthine Hydrops

Labyrinthine Vertigo

Ménière Syndrome

Ménière Vertigo

Idiopathic Endolymphatic Hydrops
Otosclerosis

Otospongiosis
Melnick-Needles Syndrome

MNS

Melnick-Needles Osteodysplasty

Osteodysplasty Of Melnick And Needles

Osteochondrodysplasias
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10839 POLR1C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris POLR1C VGNC VGNC:44790
Rattus norvegicus POLR1C RGD RGD:1309689
Bos taurus POLR1C VGNC VGNC:33133
Macaca mulatta POLR1C VGNC VGNC:76081
Mus musculus POLR1C MGD MGI:103288
Felis catus POLR1C VGNC VGNC:64287