Dnmt3l - DNA (cytosine-5-)-methyltransferase 3-like Gene

Mus musculus

Also known as ecat7; D6Ertd14e

Gene ID: 54427 | Gene type: protein coding

About Dnmt3l

Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Dnmt3l Products(6)

mRNA	Protein	Name
NM_001081695.2	NP_001075164.1	DNA (cytosine-5)-methyltransferase 3-like isoform 1
NM_001284197.1	NP_001271126.1	DNA (cytosine-5)-methyltransferase 3-like isoform 1
NM_001284198.1	NP_001271127.1	DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_001284199.1	NP_001271128.1	DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_001284200.1	NP_001271129.1	DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_019448.4	NP_062321.1	DNA (cytosine-5)-methyltransferase 3-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA (cytosine-5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	11934864	MGI
enables enzyme activator activity	IDA IDA: Inferred from direct assay	16543361	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11934864	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	24074865	MGI
acts upstream of or within autosome genomic imprinting	IMP IMP: Inferred from mutant phenotype	11934864	MGI
acts upstream of or within chorionic trophoblast cell differentiation	IMP IMP: Inferred from mutant phenotype	16920095	MGI
acts upstream of or within epigenetic programing of female pronucleus	IMP IMP: Inferred from mutant phenotype	16920095	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	22723905	MGI
involved in genomic imprinting	IMP IMP: Inferred from mutant phenotype	15318244	MGI
involved in male meiosis I	IMP IMP: Inferred from mutant phenotype	15318244	MGI
acts upstream of or within methylation	IMP IMP: Inferred from mutant phenotype	16920095	MGI
involved in negative regulation of DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	24074865	MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation	IDA IDA: Inferred from direct assay	30834655	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	16920095	MGI
acts upstream of or within post-embryonic development	IDA IDA: Inferred from direct assay	30834655	MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	25503965	MGI
involved in retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	15318244	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IPI IPI: Inferred from physical interaction	32674113	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	11934864	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	15318244	MGI
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	24074865	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	24074865	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	16543361	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16543361	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	11934864	MGI
located in nucleus	IDA IDA: Inferred from direct assay	27856912	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA (cytosine-5)-methyltransferase 3-like

Dnmt3l Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dnmt3l	Q9CWR8	Dnmt3a	Mus musculus	O88508-1	Anti Tag CoIP	17687327
Cross	Dnmt3l	Q9CWR8	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	24074865
Intra	Dnmt3l	Q9CWR8	Dnmt3b	Mus musculus	O88509	Anti Bait CoIP	24074865
Intra	Dnmt3l	Q9CWR8	Dnmt3b	Mus musculus	O88509	GMS	24074865
Intra	Dnmt3l	Q9CWR8	Dnmt3b	Mus musculus	O88509	Anti Tag CoIP	17687327
Intra	Dnmt3l	Q9CWR8	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	24074865
Intra	Dnmt3l	Q9CWR8	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	24074865
Intra	Dnmt3l	Q9CWR8	Dnmt3a	Mus musculus	O88508	Anti Bait CoIP	24074865

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03913	DNMT3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnmt3l	NCBI	NCBI:29947

Name
Email *

	Sorry, but the email address you supplied was invalid.