MIOS - meiosis regulator for oocyte development Gene

Homo sapiens

Also known as MIO; Sea4; Yulink

Gene ID: 54468 | Gene type: protein coding

About MIOS

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:7,566,884-7,609,144 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in prostate (RPKM 7.9), testis (RPKM 7.5) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

MIOS Products(5)

mRNA	Protein	Name
NM_001370076.1	NP_001357005.1	GATOR complex protein MIOS isoform 1
NM_001370077.1	NP_001357006.1	GATOR complex protein MIOS isoform 1
NM_001370078.1	NP_001357007.1	GATOR complex protein MIOS isoform 2
NM_001370080.1	NP_001357009.1	GATOR complex protein MIOS isoform 1
NM_019005.4	NP_061878.3	GATOR complex protein MIOS isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25263562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	23723238	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	35831510	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35831510	GOA
involved in protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	23723238	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	35831510	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	28199306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GATOR complex protein MIOS

H_DJ1159O04.1

MIOS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MIOS	Q9NXC5	SESN2	Homo sapiens	P58004	Anti Tag CoIP	25263562
Intra	MIOS	Q9NXC5	WDR24	Homo sapiens	Q96S15	Anti Tag CoIP	25263562
Intra	MIOS	Q9NXC5	WDR24	Homo sapiens	Q96S15	GMS	28199315

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Trichothiodystrophy 6, Nonphotosensitive

TTD6	Nonphotosensitive Trichothiodystrophy 6
Trichothiodystrophy 6, Non-Photosensitive

Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome

Sarcocystosis

Sarcosporidiosis

Sarcosporidiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08458	MIOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MIOS	VGNC	VGNC:63514
Macaca mulatta	MIOS	VGNC	VGNC:74804
Canis familiaris	MIOS	VGNC	VGNC:43239
Bos taurus	MIOS	VGNC	VGNC:31481
Rattus norvegicus	MIOS	RGD	RGD:1308432
Mus musculus	MIOS	MGD	MGI:2182066

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