SESN2 - sestrin 2 Gene

Homo sapiens

Also known as HI95; SES2; SEST2

Gene ID: 83667 | Gene type: protein coding

About SESN2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,259,518-28,282,491 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), kidney (RPKM 10.3) and 24 other tissues.

Summary

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

SESN2 Products(1)

mRNA	Protein	Name
NM_031459.5	NP_113647.1	sestrin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-leucine binding	IDA IDA: Inferred from direct assay	26449471	GOA
enables peroxidase activity	IDA IDA: Inferred from direct assay	26612684	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15105503	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	26586190	GOA
NOT enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	26449471	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25263562	GOA
NOT enables sulfiredoxin activity	IDA IDA: Inferred from direct assay	19113821	GOA
enables sulfiredoxin activity	IDA IDA: Inferred from direct assay	15105503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	18692468	GOA
NOT involved in cellular oxidant detoxification	IDA IDA: Inferred from direct assay	19113821	GOA
involved in cellular oxidant detoxification	IDA IDA: Inferred from direct assay	26612684	GOA
involved in cellular oxidant detoxification	IMP IMP: Inferred from mutant phenotype	15105503	GOA
involved in cellular response to L-leucine	IDA IDA: Inferred from direct assay	26449471	GOA
involved in cellular response to L-leucine	IMP IMP: Inferred from mutant phenotype	26586190	GOA
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	25263562	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	25457612	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	25263562	GOA
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	35114100	GOA
involved in cellular response to leucine starvation	IMP IMP: Inferred from mutant phenotype	26449471	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35114100	GOA
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	18692468	GOA
involved in negative regulation of translation in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	24947615	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	26449471	GOA
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	23274085	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	23274085	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	26612684	GOA
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	15105503	GOA
involved in regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	36528027	GOA
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	25040165	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	25040165	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15105503	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	15105503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SESN2 Protein Structure

PA26

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

sestrin-2

hypoxia induced gene 95

Related Diseases

Diseases

Alias

Pulmonary Emphysema

Nodular Ganglioneuroblastoma

Ganglioneuroblastoma, Nodular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12735	SESN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SESN2	VGNC	VGNC:77286
Bos taurus	SESN2	VGNC	VGNC:34489
Rattus norvegicus	SESN2	RGD	RGD:1566319
Canis familiaris	SESN2	VGNC	VGNC:46048
Felis catus	SESN2	VGNC	VGNC:65035
Mus musculus	SESN2	MGD	MGI:2651874

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