WDR24 - WD repeat domain 24 Gene

Homo sapiens

Also known as JFP7; C16orf21

Gene ID: 84219 | Gene type: protein coding

About WDR24

This gene has 4 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 5.5), spleen (RPKM 3.4) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of Autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

WDR24 Products(1)

mRNA	Protein	Name
NM_032259.4	NP_115635.1	GATOR complex protein WDR24

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	36528027	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	23723238	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	35831510	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	27166823	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35831510	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	36577058	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	36528027	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	27166823	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	35831510	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	28199306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR24 Protein Structure

WD40

0
200
400
600
800
920 a.a.

Protein Preferred Names

Protein Names

GATOR complex protein WDR24

WD repeat-containing protein 24

WDR24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR24	Q96S15	SZT2	Homo sapiens	Q5T011	Anti Bait CoIP	28199315
Intra	WDR24	Q96S15	SZT2	Homo sapiens	Q5T011	Crosslink	28199315
Intra	WDR24	Q96S15	SESN3	Homo sapiens	P58005	Anti Tag CoIP	26449471
Intra	WDR24	Q96S15	SESN3	Homo sapiens	P58005	Anti Tag CoIP	25263562
Intra	WDR24	Q96S15	WDR59	Homo sapiens	Q6PJI9	Anti Tag CoIP	25263562
Intra	WDR24	Q96S15	WDR59	Homo sapiens	Q6PJI9	Anti Tag CoIP	28199315
Intra	WDR24	Q96S15	WDR59	Homo sapiens	Q6PJI9	Anti Bait CoIP	28199315
Intra	WDR24	Q96S15	WDR59	Homo sapiens	Q6PJI9	GMS	28199315
Intra	WDR24	Q96S15	WDR59	Homo sapiens	Q6PJI9	Crosslink	28199315
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Bait CoIP	25263562
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	25263562
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Bait CoIP	26449471
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Bait CoIP	28199315
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Bait CoIP	26972053
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	28199315
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26972053
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26586190
Intra	WDR24	Q96S15	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26449471
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Tag CoIP	26449471
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Tag CoIP	26586190
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Bait CoIP	25263562
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Tag CoIP	28199315
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Tag CoIP	25263562
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Bait CoIP	26449471
Intra	WDR24	Q96S15	SESN2	Homo sapiens	P58004	Anti Bait CoIP	26972053
Intra	WDR24	Q96S15	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	WDR24	Q96S15	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15768	WDR24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDR24	MGD	MGI:2446285
Canis familiaris	WDR24	VGNC	VGNC:48356
Rattus norvegicus	WDR24	RGD	RGD:1304803
Bos taurus	WDR24	VGNC	VGNC:36887
Macaca mulatta	WDR24	VGNC	VGNC:79289
Felis catus	WDR24	VGNC	VGNC:67021

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