RBM47 - RNA binding motif protein 47 Gene

Homo sapiens

Also known as NET18

Gene ID: 54502 | Gene type: protein coding

About RBM47

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,423,280-40,630,852 (from NCBI)

This gene has 15 transcripts (splice variants), 203 orthologues and 36 paralogues. Broad expression in colon (RPKM 20.7), kidney (RPKM 20.0) and 22 other tissues.

Summary

Enables RNA binding activity. Predicted to act upstream of or within cytidine to uridine editing and hematopoietic progenitor cell differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RBM47 Products(4)

mRNA	Protein	Name
NM_001098634.2	NP_001092104.1	RNA-binding protein 47 isoform a
NM_001371113.1	NP_001358042.1	RNA-binding protein 47 isoform a
NM_001371114.1	NP_001358043.1	RNA-binding protein 47 isoform c
NM_019027.4	NP_061900.2	RNA-binding protein 47 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	24038582	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	24916387	GOA
enables enzyme-substrate adaptor activity	IDA IDA: Inferred from direct assay	24916387	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	34160127	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24916387	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	34160127	GOA
involved in cytidine to uridine editing	IDA IDA: Inferred from direct assay	24916387	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	34160127	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	31358901	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of apolipoprotein B mRNA editing enzyme complex	IDA IDA: Inferred from direct assay	24916387	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24916387	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24038582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM47 Protein Structure

RRM_1

0
100
200
300
400
500
593 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 47

RBM47 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM47	A0AV96	FAM22F	Homo sapiens	B7ZLH0	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	FAM22F	Homo sapiens	B7ZLH0	Validated Y2H	32296183
Intra	RBM47	A0AV96	FAM22F	Homo sapiens	B7ZLH0	Y2H Array	32296183
Intra	RBM47	A0AV96	PCBP3	Homo sapiens	P57721-2	Validated Y2H	32296183
Intra	RBM47	A0AV96	ZNF385C	Homo sapiens	Q66K41-2	Validated Y2H	32296183
Intra	RBM47	A0AV96	RBM46	Homo sapiens	Q8TBY0	Anti Tag CoIP	33961781
Intra	RBM47	A0AV96	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
Intra	RBM47	A0AV96	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
Intra	RBM47	A0AV96	CELF5	Homo sapiens	Q8N6W0	Validated Y2H	32296183
Intra	RBM47	A0AV96	CELF5	Homo sapiens	Q8N6W0	Y2H Array	32296183
Intra	RBM47	A0AV96	CELF5	Homo sapiens	Q8N6W0	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	C10orf55	Homo sapiens	Q5SWW7	Validated Y2H	32296183
Intra	RBM47	A0AV96	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	RBM47	A0AV96	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	RBM47	A0AV96	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	RBM47	A0AV96	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	PRR13	Homo sapiens	Q9NZ81	Y2H Array	32296183
Intra	RBM47	A0AV96	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
Intra	RBM47	A0AV96	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	RBM47	A0AV96	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	OTX2	Homo sapiens	P32243-2	Validated Y2H	32296183
Intra	RBM47	A0AV96	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183
Intra	RBM47	A0AV96	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	RBM47	A0AV96	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11755	RBM47 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBM47	VGNC	VGNC:53198
Rattus norvegicus	RBM47	RGD	RGD:1359713
Bos taurus	RBM47	VGNC	VGNC:33804
Macaca mulatta	RBM47	VGNC	VGNC:76576
Felis catus	RBM47	VGNC	VGNC:64535
Mus musculus	RBM47	MGD	MGI:2384294

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