2. Gene
  3. CELF5 - CUGBP Elav-like family member 5 Gene

CELF5 - CUGBP Elav-like family member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CELF-5; BRUNOL5; BRUNOL-5

Gene ID: 60680 | Gene type: protein coding

About CELF5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,224,661-3,297,076 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 6 paralogues. Biased expression in brain (RPKM 14.1), ovary (RPKM 2.1) and 1 other tissue.

Summary

This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CELF5 Products(2)

mRNA Protein Name
NM_001172673.2 NP_001166144.1 CUGBP Elav-like family member 5 isoform 2
NM_021938.4 NP_068757.2 CUGBP Elav-like family member 5 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
11158314 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELF5 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (47 - 113)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (136 - 198)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (402 - 471)

  • 0
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  • 200
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  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 5

CUG-BP and ETR-3 like factor 5

CELF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra CELF5 Q8N6W0 VASN Homo sapiens Q6EMK4
Y2H Array
32296183
Intra CELF5 Q8N6W0 VASN Homo sapiens Q6EMK4
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra CELF5 Q8N6W0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra CELF5 Q8N6W0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra CELF5 Q8N6W0 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Y2H Array
32296183
Intra CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Validated Y2H
32296183
Intra CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Specific Language Impairment

Language Impairment, Specific
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02463 CELF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CELF5 VGNC VGNC:60747
Mus musculus CELF5 MGD MGI:2442333
Rattus norvegicus CELF5 RGD RGD:1565016
Canis familiaris CELF5 VGNC VGNC:39096
Bos taurus CELF5 VGNC VGNC:55204
Macaca mulatta CELF5 VGNC VGNC:109597